Publications on bio-microtechnologies

Patents

Fujii T, Sakai Y , Leclerc E. (in japanese, « cell culture chamber ») no 2002-321859

Fujii T, Sakai Y , Leclerc E (in japanese, « cell culture device, bioreactor and cell culture chamber »)  no 2002-316136

Chapter in Book

Sakai Y., Leclerc E., Fujii T., Microfluidc Cell-culture Devices, towards in vitro Liver Tissue Reconstruction, Lab on chips for cellomics, chapter 12, Micro and nanotechnologies for life science, Kluwer Academic publishers, pp 299-318, 2004

Journal Papers

Baudoin R., Duval J.L., Griscom L., Baudoin R., Legallais C., Leclerc E., Selective control of liver and kidney cells migration  during organotypic co-cultures inside fibronectin coated rectangular  silicone microchannelsBiomaterials, accepted , in press

Baudoin R., Corlu A., Griscom L., Legallais C., Leclerc E., Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity, Toxicology in vitro, accepted, in press

Leclerc E., Corlu A., Griscom L., Baudoin R., Legallais C.,Guidance of liver and kidney organotipic cultures inside rectangular silicone microchannelsBiomaterials, 27:22, 4109-4119, 2006

Leclerc E., David B., Griscom L., Lepioufle B., Fujii T., Sakai Y., Legallais C., Perfusion culture of mammalian cells in microfluidic environments for tissue engineering applications, La houille blanche, 3, 2006

Leclerc E., David B., Griscom L., Lepioufle B., Fujii T., Layrolle P., Legallais C.,  Study of osteoblastic cells in a microfluidic environmentBiomaterials, 27:4, 586-595, 2006

Leclerc E., Sakai Y. and Fujii T., A microfluidic PDMS (polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes , Biotechnology Progress, 20:3, 750-755, 2004

Leclerc E., Furukawa K.S., Miyata F., Sakai Y., Ushida T., Fujii T., Effect on liver cells of stepwise microstructures fabricated in a photosensitive biodegradable polymer by softlithographyMaterials Science and Engineering: C, 24:3, 349-354, 2004

Leclerc E., Sakai Y., Fujii T., Perfusion Culture of Fetal Human Hepatocytes in Microfluidic-Environments, Biochemical Engineering Journal, 20, 143-148, 2004

Leclerc E., Furukawa K.S., Miyata F., Sakai Y.,Ushida T., Fujii T., Fabrication of microstructures in photosensitive biodegradable polymers for tissue engineering applications,  Biomaterials, 25, 4683-4690, 2004

Leclerc E. Sakai Y., Fujii T., Cells culture in a three-dimensional network of PDMS (PolyDiMethylSiloxane) microchannels, biomedical microdevices, 5:2, 109-114, 2003

Publications in journals linked to fluid mechanics

Leclerc E, Berthoud G, Modelling of melt droplet fragmentation following vapor film destabilisation by a trigger pulse, Nuclear Technology,  144:2, 158-174, 2003

Chpoun A, Leclerc E, Experimental investigation of the influence of downstream flow conditions on Mach Stem height, Shock Waves, 9: 269-271, 1999