2000


1. Andrievskaya OA, Buneva VN, Naumov VA & Nevinsky GA
Catalytic heterogeneity of polyclonal RNA-hydrolyzing IgM from sera of patients with lupus erythematosus.
Med. Sci. Monit. 6 (2000) 460-470

2. Avalle B, Débat H, Friboulet A & Thomas D
Catalytic mechanism of an abzyme displaying a -lactamase-like activity.
Appl. Biochem. Biotechnol. 83 (2000) 163-171

3. Avalle B, Friboulet A & Thomas D
Catalysis by anti-idiotypic antibodies.
Chem. Immunol. 77 (2000) 80-88

4. Avalle B, Friboulet A & Thomas D
Enzymes and abzymes relationships.
J. Mol. Catal. 10 (2000) 39-45

5. Blackburn GM & Garçon A
Catalytic antibodies
in "Biotechnology" Vol. 8b, 2nd edition, HJ Rehm & G Reed eds, Wiley VCH (2000) 404-490

6. Cashman JR, Berkman CE & Underiner GE
Catalytic antibodies that hydrolyze (-)-cocaine obtained by a high-throughput procedure.
J. Pharm. Exp. Therap. 293 (2000) 952-961

7. Chen JG, Deng QL, Wang RX, Houk KN & Hilvert D
Shape complementarity, binding-site dynamics, and transition state stabilization: a theoretical study of Diels-Alder catalysis by antibody 1E9.
Chembiochem 1 (2000) 255-261

8. De Prada P, Winger G & Landry DW
Application of artificial enzymes to the problem of cocaine.
Ann. NY Acad. Sci. 909 (2000) 159-169

9. De Silva BS, Wilson GS & Schowen RL
Catalyst design for reactions with multiple transition states.
Chem. Immunol. 77 (2000) 33-57

10. Débat H, Avalle B, Friboulet A & Thomas D
Structure-function studies of a new generation of catalytic protein: an abzyme with a beta-lactamase activity.
Int. J. Bio-Chromatogr. 5 (2000) 91-96

11. DeSilva BS, Orosz G, Egodage KL, Carlson RG, Schowen RL & Wilson SG
Catalytic antibodies for complex reactions.
Appl. Biochem. Biotechnol. 83 (2000) 195-208

12. Dinaut AN, Chen MJ, Marks A, Batey RA & Taylor SD
Hydrolysis of an N-methylcarbamate by a catalytic antibody.
Chem. Commun. (2000) 385-386

13. Gill I & Ballesteros A
Bioencapsulation within synthetic polymers (part I): sol-gel encapsulated biologicals.
Trends Biotechnol. 18 (2000) 282-296

14. Golinelli-Pimpaneau B
Novel reactions catalysed by antibodies.
Curr. Opin. Struct. Biol. 10 (2000) 697-708

15. Golinelli-Pimpaneau B, Gonçalves O, Dintinger T, Blanchard D, Knossow M & Tellier C
Structural evidence for a programmed general base in the active site of a catalytic antibody.
Proc. Natl. Acad. Sci. USA 97 (2000) 9892-9895

16. Gololobov G, Tramontano A & Paul S
Nucleophilic proteolytic antibodies.
Appl. Biochem. Biotechnol. 83 (2000) 221-232

17. Gonçalves O, Dintinger T, Lebreton J, Blanchard D & Tellier C
Mechanism of an antibody-catalysed allylic isomerization.
Biochem. J. 346 (2000) 691-698

18. Gramatikova SI & Christen P
Pyridoxal-5'-phosphate-dependent catalytic antibodies.
Appl. Biochem. Biotechnol. 83 (2000) 183-193

19. Harwig CW, Hoffman TZ, Wentworth AD & Janda KD
A one-pot multistep approach to alpha-azido-phosphonate and phosphonothioate diesters: key intermediates in the synthesis of haptens for the generation of antibody ligases.
Bioorg. Med. Chem. Lett. 10 (2000) 915-918

20. Hasserodt J, Janda KD & Lerner RA
A class of 4-aza-lithocholic acid-derived haptens for the generation of catalytic antibodies with steroid synthase capabilities.
Bioorg. Med. Chem. 8 (2000) 995-1003

21. Hasserodt J, Janda KD & Lerner RA
Antibodies mimic natural oxidosqualene-cyclase action in steroid ring A formation.
J. Am. Chem. Soc. 122 (2000) 40-45

22. Hertweck C
Aldolase antibody 38C2: a biocatalyst expanding the scope of enzymatic transformations.
J. Prak. Chem. 342 (2000) 832-835

23. Hetherington L, Greedy B & Gouverneur V
Ring-closing olefin metathesis for the synthesis of phosphorus containing heterocycles.
Tetrahedron 56 (2000) 2053-2060

24. Hifumi E, Ohara K, Niimi Y & Uda T
Removal of catalytic activity by EDTA from antibody light chain.
Biometals 13 (2000) 289-294

25. Hifumi E, Okamoto Y & Uda T
How and why 41S-2 antibody subunits acquire the ability to catalyze decomposition of the conserved sequence of gp41 of HIV-1.
Appl. Biochem. Biotechnol. 83 (2000) 209-220

26. Hilvert D
Critical analysis of antibody catalysis.
Annu. Rev. Biochem. 69 (2000) 751-793

27. Hollfelder F, Kirby AJ, Tawfik DS, Kikuchi K & Hilvert D
Characterization of proton-transfer catalysis by serum albumin.
J. Am. Chem. Soc. 122 (2000) 1022-1029

28. Hotta K, Lange H, Tantillo DJ, Houk KN, Hilvert D & Wilson IA
Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structure of abzyme 21D8.
J. Mol. Biol. 302 (2000) 1213-1225

29. Hum G, Wooler K, Lee J & Taylor SD
Cyclic five-membered phosphinate esters as transition state analogues for obtaining phosphohydrolase antibodies.
Can. J. Chem. 78 (2000) 642-655

30. Johnson G & Moore SW
Localization of a novel adhesion-promoting site on acetylcholinesterase using catalytic antiacetylcholinesterase antibodies displaying cholinesterase-like activity.
Appl. Biochem. Biotechnol. 83 (2000) 131-144

31. Johnson G & Moore SW
Cholinesterase-like catalytic antibodies: reaction with substrates and inhibitors.
Mol. Immunol. 37 (2000) 707-719

32. Karlstrom A, Zhong G, Rader C, Larsen NA, Heine A, Fuller R, List B, Tanaka F, Wilson IA, Barbas III CF & Lerner RA
Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task.
Proc. Natl. Acad. Sci. USA 97 (2000) 3878-3883

33. Kazlauskas RJ
Molecular modeling and biocatalysis: explanations, predictions, limitations, and opportunities.
Curr. Opin. Chem. Biol. 4 (2000) 81-88

34. Kirby AJ, Hollfelder F & Tawfik DS
Nonspecific catalysis by protein surfaces.
Appl. Biochem. Biotechnol. 83 (2000) 173-181

35. Kolesnikov AV, Kozyr AV, Alexandrova EA, Koralewski F, Demin AV, Titov MI, Avalle B, Tramontano A, Paul S, Thomas D, Gabibov AG & Friboulet A
Enzyme mimicry by the antiidiotypic antibody approach.
Proc. Natl. Acad. Sci. USA 97 (2000) 13526-13531

36. Konorev MR
Antibody enzymes in Helicobacter pylori-associated infection.
Zh. Mikrobiol. Epidemiol. Immunobiol. 1 (2000) 75-79

37. Konorev MR, Okulich VK, Generalov LI, Senkovich SA & Generalova AG
Urease-like IgG antibodies in H-pylori-positive patients.
J. Immunopathol. 1 (2000) 110-13

38. Kozyr AV, Kolesnikov AV, Zelenova NA, Sashchenko LP, Mikhalap SV, Bulina ME, Ignatova AN, Favorov PV & Gabibov AG
Autoantibodies to nuclear antigens.
Appl. Biochem. Biotechnol. 83 (2000) 255-269

39. Kurihara S, Tsumuraya T, Suzuki K, Kuroda M, Liu L, Takaoka Y & Fujii I
Antibody-catalyzed removal of the p-nitrobenzyl ester protecting group: the molecular basis of broad substrate specificity.
Chem. Eur. J. 6 (2000) 1656-1662

40. Lacroix-Desmazes S, Sooryanarayana, Moreau A, Horn MP, Kazatchkine MD & Kaveri SV
Factor VIII inhibitor with catalytic activity towards Factor VIII.
Chem. Immunol. 77 (2000) 102-114

41. Lacroix-Desmazes S, Sooryanarayana, Moreau A, Kazatchkine MD & Kaveri SV
Factor VIII with catalytic activity towards factor VIII.
Haematologica (Roma) 85 (2000) 89-92

42. Li L, Kalaga R & Paul S
Proteolytic components of serum IgG preparations.
Clin. Exp. Immunol. 120 (2000) 261-266.

43. Luo GM
Recent advances in abzyme studies.
Prog. Biochem. Biophys. 27 (2001) 354-359

44. Machajewski TD & Wong CH
The catalytic asymmetric aldol reaction.
Angew. Chem. 39 (2000) 1352-1375

45. Matsuura K, Ikoma S, Sugiyama M, Funauchi M & Sinohara H
Amidase and peptidase activities of polyclonal immunoglobulin G present in sera of patients with rheumatoid arthritis.
Appl. Biochem. Biotechnol. 83 (2000) 107-114

46. Mehta PK & Christen P
The molecular evolution of pyridoxal-5'-phosphate dependent enzymes.
Adv. Enzymol. 74 (2000) 129-184

47. Mouratou B, Gramatikova S, Kunz B & Christen P
Amino acid sequences and hapten binding of catalytic and noncatalytic antibodies against N-(5'-phosphopyridoxyl)-L-lysine.
Mol. Immunol. 37 (2000) 633-640

48. Mundorff EC, Hanson MA, Varvak A, Ulrich H, Schultz PG & Stevens RC
Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement.
Biochemistry 39 (2000) 627-632

49. Nedonchelle E, Pitiot O & Vijayalakshmi MA
A preliminary study for isolation of catalytic antibodies by histidine ligand affinity chromatography as an alternative to conventional Protein A/G methods.
Appl. Biochem. Biotechnol. 83 (2000) 287-295

50. Nevinsky GA, Kanyshkova TG & Buneva VN
Natural catalytic antibodies (abzymes) in normalcy and pathology.
Biochemistry (Mosc.) 65 (2000) 1245-1255

51. Nevinsky GA, Kanyshkova TG, Semenov DV, Vlassov AV, Gal'Vita AV & Buneva VN
Secretory immunoglobulin A from healthy human mothers' milk catalyzes nucleic acid hydrolysis.
Appl. Biochem. Biotechnol. 83 (2000) 115-130

52. Nevinsky GA, Semenov DV & Buneva VN
Catalytic antibodies (abzymes) induced by stable transition-state analogs.
Biochemistry (Mosc.) 65 (2000) 1233-1244

53. Nishi Y, Takahashi N, Kakinuma H & Sun J
Catalytic antibodies in autoimmune mice.
Chem. Immunol. 77 (2000) 58-79

54. Odenbaugh AL, Helms ED & Iverson BL
An investigation of antibody acyl hydrolysis catalysis using a large set of related haptens.
Bioorg. Med. Chem. 8 (2000) 413-426

55. Paul S, Kalaga RS, Gololobov G & Brenneman D
Natural catalytic immunity is not restricted to autoantigenic substrates.
Appl. Biochem. Biotechnol. 83 (2000) 71-84

56. Perez Carlon R, Jourdain N & Reymond JL
Fluorogenic polypropionate fragments for detecting stereoselective aldolases.
Chem. Eur. J. 6 (2000) 4154-4162

57. Ponomarenko NA, Aleksandrova ES, Vorobiev II, Durova OM, Kozyr AV, Kolesnikov AV, Telegon GB, Kalinina AR, Suchkov SV & Gabibov AG
Natural antibody catalytic activities in mice with autoimmune disorders.
Dokl. Biochem. 375 (2000) 224-227

58. Rader C & List B
Catalytic antibodies as magic bullets.
Chem. Eur. J. 6 (2000) 2091-2095

59. Resmini M, Gul S, Carter S, Sonkaria S, Topham CM, Gallacher G & Brocklehurst K
A general kinetic approach to investigation of active-site availability in macromolecular catalysts.
Biochem. J. 346 (2000) 117-125

60. Ritzeler O, Parel S, Therrien B, Bensel N, Reymond JL & Schenk K
Atropisomeric transition state analog.
Eur. J. Org. Chem. 11 (2000) 1365-1372

61. Rodkey LS, Gololobov G, Rumbley CA, Rumbley J, Schourov DV, Makarevich OI, Gabibov AG & Voss Jr EW
DNA hydrolysis by monoclonal autoantibody BV 04-01.
Appl. Biochem. Biotechnol. 83 (2000) 95-105

62. Rose NR & Burek CL
Autoantibodies to thyroglobulin in health and disease.
Appl. Biochem. Biotechnol. 83 (2000) 245-254

63. Shimazaki K, Kakinuma H, Takahashi K, Niihata S, Takahashi N, Matsushita H, Nishi y & Sakakibara K
Ab inition study toward designing transition-state analogues which elicit proteolytic catalytic antibodies.
J. Phys. Org. Chem. 13 (2000) 167-175

64. Shreder K
Synthetic haptens as probes of antibody response and immunorecognition.
Methods 20 (2000) 372-379

65. Shulman H, Eberhard A, Eberhard C, Ulitzur S & Keinan E
Highly sensitive and rapid detection of antibody catalysis by luminescent bacteria.
Bioorg. Med. Chem. Lett. 10 (2000) 2353-2356

66. Shulman H, Makarov C, Ogawa AK, Romesberg F & Keinan E
Chemically reactive immunogens lead to functional convergence of the immune response.
J. Am. Chem. Soc. 122 (2000) 10743-10753

67. Simeonov A, Matsushita M, Juban EA, Thompson EHZ, Hoffman TZ, Beuscher IV AE, Taylor MJ, Wirsching P, Rettig W, McCusker JK, Stevens RC, Millar DP, Schultz PG, Lerner RA & Janda KD
Blue-fluorescent antibodies.
Science 290 (2000) 307-313

68. Sinha SC, Dutta S & Sun J
Regioselective synthesis of fluoroaldols. Studies toward fluoroepothilones syntheses via antibody catalysis.
Tetrahedron Lett. 41 (2000) 8243-8246

69. Sinohara H & Matsuura K
Does catalytic activity of Bence-Jones proteins contribute to the pathogenesis of multiple myeloma?
Appl. Biochem. Biotechnol. 83 (2000) 85-94

70. Sinohara H & Matsuura K
Catalytic activities and functional effects of Bence Jones Proteins.
Chem. Immunol. 77 (2000) 89-101

71. Smithrud DB, Benkovic PA, Benkovic SJ, Roberts V, Liu J, Neagu I, Iwama S, Phillips BW, Smith III AB & Hirschmann R
Cyclic peptide formation catalyzed by an antibody ligase.
Proc. Natl. Acad. Sci. USA 97 (2000) 1953-1958

72. Stevenson JD & Thomas NR
Catalytic antibodies and other biomimetic catalysts.
Nat. Prod. Rep. 17 (2000) 535-577

73. Sutcliffe MJ & Scrutton NS
Enzyme catalysis: over-the-barrier or through the barrier?
Trends Biochem. Sci. 25 (2000) 405-408

74. Suzuki H, Higashi Y, Naitoh N, Yamamoto C, Nakamura S & Kawamura-Konishi Y
Chemical modification of a catalytic antibody that accelerates the hydrolysis of carbonate esters.
J. Protein Chem. 19 (2000) 419-424

75. Takahashi N, Kikunuma H, Hamada K, Shimazaki K, Yamasaki Y, Matsushita H & Nishi Y
Improved generation of catalytic antibodies by MRL/MPJ-lpr/lpr autoimmune mice.
J. Immunol. Meth. 235 (2000) 113-120

76. Tanaka F, Lerner RA & Barbas III C
Reconstructing aldolase antibodies to alter their substrate specificity and turnover.
J. Am. Chem. Soc. 122 (2000) 4835-4836

77. Thiagarajan P & Paul S
Prothrombin cleaving antibody light chains.
Chem. Immunol. 77 (2000) 115-129

78. Thiagarajan P, Dannenbring R, Matsuura K, Tramontano A, Gololobov G & Paul S
Monoclonal antibody light chain with prothrombinase activity.
Biochemistry 39 (2000) 6459-6465

79. Toker JD, Wentworth P, Yunfeng H, Houk KN & Janda KD
Antibody-catalysis of a bimolecular asymmetric 1,3-dipolar cycloaddition reaction.
J. Am. Chem. Soc. 122 (2000) 3244-3245

80. Topham CM, Gul S, Resmini M, Sonkaria S, Gallacher G & Brocklehurst K
The kinetic basis of a general method for the investigation of active site content of enzymes and catalytic antibodies: First-order behaviour under single-turnover and cycling conditions.
J. Theor. Biol. 204 (2000) 239-256

81. Tramontano A, Gololobov G & Paul S
Proteolytic antibodies: origins, selection and induction.
Chem. Immunol. 77 (2000) 1-17

82. Tramontano A, Ivanov B, Gololobov G & Paul S
Inhibition and labeling of enzymes and abzymes by phosphonate diesters.
Appl. Biochem. Biotechnol. 83 (2000) 233-243

83. Turner JM, Bui T, Lerner RA, Barbas III CF & List B
An efficient benchtop system for multigram-scale kinetic resolutions using aldolase antibodies.
Chem. Eur. J. 6 (2000) 2772-2774

84. Uda T, Hifumi E, Ohara K & Zhou Y
Catalytic activity of antibody light chain to gp41: a consideration of refolding in relation to activation mechanism.
Chem. Immunol. 77 (2000) 18-32

85. Vayron P, Renard PY, Taran F, Créminon C, Frobert Y, Grassi J & Mioskowski C
Toward antibody-catalyzed hydrolysis of organophosphorus poisons.
Proc. Natl. Acad. Sci. USA 97 (2000) 7058-7063

86. Vayron P, Renard PY, Valleix A & Mioskowski C
Design and synthesis of an alpha-alpha-difluorophosphinate hapten for antibody-catalyzed hydrolysis of organophosphorus nerve agents.
Chem. Eur. J. 6 (2000) 1050-1063

87. Wang ZL, Rong KT, Yang RF & Yun LH
Gamma-hydroxyphosphonate inducing single-chain antibodies capable of catalyzing soman hydrolysis.
Science-China Ser.B Chemistry 43 (2000) 649-656

88. Wentworth AD, Jones LH, Wentworth P, Janda KD & Lerner RA
Antibodies have the intrinsic capacity to destroy antigens.
Proc. Natl. Acad. Sci. USA 97 (2000) 10930-10935

89. Zhan CG, Landry DW & Ornstein RL
Theoretical studies of fundamental pathways for alkaline hydrolysis of carboxylic acid esters in gas phase.
J. Am. Chem. Soc. 122 (2000) 1522-1530

90. Zhan CG, Landry DW & Ornstein RL
Reaction pathways and energy barriers for alkaline hydrolysis of carboxylic acid esters in water studied by a hybrid supermolecule-polarizable continuum approach.
J. Am. Chem. Soc. 122 (2000) 2621-2627




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