2001


1. Alexandrova ES, Koralewski F, Titov MI, Demin AV, Ignatova AN, Kozyr AV, Kolesnikov AV, Tramontano A, Paul S, Thomas D, Gabibov AG & Friboulet A
Catalysis of esterolytic reaction by an acetylcholinesterase antiidiotypic antibody.
Dokl. Akad. Nauk (Russian) 377 (2001) 256-259

2. Arno M & Domingo LR
Using theozymes for designing transition-state analogs for the intramolecular aldol reaction of delta-diketones.
Int. J. Quant. Chem. 83 (2001) 338-347

3. Baranovskii AG, Ershova NA, Buneva VN, Kanyshkova TG, Mogelnitskii AS, Doronin BM, Boiko AN, Gusev EI, Favorova OO & Nevinsky GA
Catalytic heterogeneity of polyclonal DNA-hydrolyzing antibodies from the sera of patients with multiple sclerosis.
Immunol. Letters 76 (2001) 163-167

4. Ben-Chaim M
The scientific discovery of "natural capital": the production of catalytic antibodies.
Stud. Hist. Phil. Biol. Biomed. Sci. 32 (2001) 413-433

5. Benedetti F, Berti F, Colombatti A, Flego M, Gardossi L, Linda P & Peressini S
Antibody catalyzed modification of amino acids. Efficient hydrolysis of tyrosine benzoate.
Chem. Commun. 8 (2001) 715-716

6. Bensel N, Reymond MT & Reymond JL
Pivalase catalytic antibodies: towards abzymatic activation of prodrugs.
Chem. Eur. J. 7 (2001) 4604-4612

7. Briscoe RJ, Jeanville PM, Cabrera C, Baird TJ, Woods JH & Landry DW
A catalytic antibody against cocaine attenuates cocaine's cardiovascular effects in mice: a dose and time course analysis.
Int. Immunopharmacol. 1 (2001) 1189-1198

8. Brocklehurst K, Resmini M & Topham CM
Kinetic and titration methods for determination of active site contents of enzyme and catalytic antibody preparations.
Methods 24 (2001) 153-167

9. Brummer O, Hoffman TZ & Janda KD
Metalloantibodies: Mercury(II)-dependent acyl transferases.
Bioorg. Med. Chem. 9 (2001) 2253-2257

10. Brummer O, Hoffman TZ, Chen DW & Janda KD
Antibody-catalyzed hydrolysis of oligomeric esters: a model for the degradation of polymeric materials.
Chem. Commun. 8 (2001) 19-20

11. Chen DW, Kubiak RJ, Ashley JA & Janda KD
Reactive immunization elicits catalytic antibodies for polyester hydrolysis.
J. Chem. Soc., Perkin trans. 1, 21 (2001) 2796-2803

12. Chen J, Wang R, Taussig M & Houk KN
Quantitative calculations of antibody-antigen binding: steroid db3 binding energies by the linear interaction energy method.
J. Org. Chem. 66 (2001) 3021-3026

13. Chen Y & Reymond JL
Enantioselective epoxidation with a library of catalytic antibodies.
Synthesis 6 (2001) 934-936

14. Cordova A & Janda KD
Synthesis and catalytic antibody functionalization of dendrimers.
J. Am. Chem. Soc. 123 (2001) 8248-8259

15. Débat H, Avalle B, Chose O, Sarde CO, Friboulet A & Thomas D
Overpassing an aberrant Vk gene to sequence an anti-idiotypic abzyme with -lactamase-like activity that could have a linkage with autoimmune disease.
FASEB J. 15 (2001) 815-822

16. Dinaut AN & Taylor SD
Antibody-catalyzed activation of a model tripartate prodrug by a tandem hydrolysis-1,6-elimination reaction.
Chem. Commun. 8 (2001) 1386-1386

17. Duclos S, Stoeckli-Evans H & Ward T
Design and synthesis of compartmental ligands and their complexes for the production of catalytic antibodies.
Helv. Chim. Acta 84 (2001) 3148-3161

18. Fang F, Wang L, Qi XJ, Yan XY, Ding L, Zhao DQ & Ni JZ
Human catalytic antibodies with glutathione peroxidase activity.
J. Inorg. Biochem. 85 (2001) 301-307

19. Fessner WD & Helaine V
Biocatalytic synthesis of hydroxylated natural products using aldolases and related enzymes.
Curr. Opin. Biotechnol. 12 (2001) 574-586

20. Hilvert D
Enzyme engineering.
Chimia 55 (2001) 867-869

21. Huang H, Han WG, Noodleman L & Grynszpan F
Multiple reactive immunization towards the hydrolysis of organophosphorus nerve agents: hapten design and synthesis.
Bioorg. Med. Chem. 9 (2001) 3185-3195

22. James LC & Tawfik DS
Catalytic and binding poly-reactivities shared by two unrelated proteins: the potential role of promiscuity in enzyme evolution.
Protein Sci. 10 (2001) 2600-2607

23. Jimenez C & Tramontano A
Synthesis of a new hapten for generating catalytic antibodies that activate doxorubicin prodrugs.
Tetrahedron Lett. 42 (2001) 7819-7822

24. Johnston N
Weapons of tumor mass destruction researchers are using catalytic antibodies to target and destroy cancers.
Todays Chemist at Work 10 (2001) 30-37

25. Jones LH, Harwig GW, Wentworth P, Simeonov A, Wentworth AD Py S, Ashley JA, Lerner RA & Janda KD
Conversion of enediynes into quinones by antibody catalysis and in aqueous buffers: implications for an alternative enediyne therapeutic mechanism.
J. Am. Chem. Soc. 123 (2001) 3607-3608

26. Junghun S
Synthesis of polymeric enzyme-like catalysts.
Synlett. 9 (2001) 1343-1363

27. Junghun S & Moon SJ
Artificial peptidase with an active site comprising a Cu(II) center and a proximal guanidinium ion. A carboxypeptidase A analogue.
Inorg. Chem. 40 (2001) 4890-4895

28. Kamei H, Shimazaki K & Nishi Y
Computational 3-D modeling and site-directed mutation of an antibody that binds Neu2en5Ac, a transition state analogue of sialic acid.
Proteins 45 (2001) 285-296

29. Kim GT, Wenz M, Park JI, Hasserodt J & Janda KD
Polyene substrates with unusual methylation patterns to probe the active sites of three catalytic antibodies.
Bioorg. Med. Chem. (2001) online 7/12/2001

30. Kuhar MJ, Carroll FI, Bharat N & Landry DW
Anticocaine catalytic antibodies have no affinity for RTI compounds: implications for treatment.
Synapse 41 (2001) 176-178

31. Larrick JW, Yu LY, Naftzger C, Jaiswal S & Wycoff K
Production of secretory IgA antibodies in plants.
Biomol. Eng. 18 (2001) 87-94

32. Larsen NA, Heine A, Crane L, Cravatt BF, Lerner RA & Wilson I
Structural basis for a disfavored elimination reaction in catalytic antibody 1D4.
J. Mol. Biol. 314 (2001) 93-102

33. Lefèvre S, Débat H, Thomas D, Friboulet A & Avalle B
A suicide-substrate mechanism for hydrolysis of beta-lactams by an anti-idiotypic catalytic antibody.
FEBS Letters 489 (2001) 25-28

34. Lian G, Ding L, Chen M, Liu L, Zhao D & Ni J
A selenium-containing catalytic antibody with type-I deiodinase activity.
Biochem. Biophys. Res. Commun. 283 (2001) 1007-1012

35. Lian G, Ding L, Chen M, Liu Z, Zhao D & Ni J
Preparation and properties of selenium-containing catalytic antibody as type-I iodothyronine deiodinase mimic.
J. Biol. Chem. 276 (2001) 28037-28041

36. Luo GM, Qi DH, Zheng YG, Mu Y, Yan GL, Yang Ts & Shen JC
ESR studies on reaction of saccharide with the free radicals generated from the xanthine oxidase/hypoxanthine system containing iron.
FEBS Letters 492 (2001) 29-32

37. Matsushita M, Hoffman TZ, Ashley JA, Zhou B, Wirsching P & Janda KD
Cocaine catalytic antibodies: the primary importance of linker effects.
Bioorg. Med. Chem. Lett. 11 (2001) 87-90

38. Motherwell WB, Bingham MJ & Six Y
Recent progress in the design and synthesis of artificial enzymes.
Tetrahedron 57 (2001) 4663-4686

39. Muranova TA, Ruzheinikov SN, Sedelnikova SE, Moir A, Partridge LJ, Kakinuma H, Takahashi N, Shimazaki K, Sun J, Nishi Y & Rice DW
The preparation and crystallization of Fab fragments of a family of mouse esterolytic catalytic antibodies and their complexes with a transition-state analogue.
Acta Crystallogr. D 57 (2001) 1192-1195

40. Nevinsky GA, Breusov AA, Baranovskii AG, Prints AV, Kanyshkova TG, Galvita AV, Naumov VA & Buneva VN
Effect of different drugs on the level of DNA-hydrolyzing polyclonal IgG antibodies in sera of patients with Hashimoto's thyroiditis and nontoxic nodal goiter.
Med. Sci. Monit. 7 (2001) 201-211

41. Orencia MC, Hanson MA & Stevens RC
Structural analysis of affinity matured antibodies and library-evolved enzymes.
Adv. Prot. Chem. 55 (2001) 227-259

42. Paul S, Tramontano A, Gololobov G, Zhou YX, Tagushi H, Karle S, Nishiyaama Y, Planque S & George S
Phosphonate ester probes for proteolytic antibodies.
J. Biol. Chem. 276 (2001) 28314-28320

43. Pohnert G
Diels-Alderases.
Chembiochem. 2 (2001) 873-875

44. Rader C
Antibody libraries in drug and target discovery.
Drug Discovery Today 6 (2001) 36-43

45. Ren X, Gao S, You D, Huang H, Liu Z, Mu Y, Liu J, Zhang Y, Yan G, Luo G, Yang T & Shen J
Cloning and expression of a single-chain catalytic antibody that acts as a glutathione peroxidase mimic with high catalytic efficiency.
Biochem. J. 359 (2001) 369-374

46. Reymond JL
New high-throughput screening assays for biocatalysis.
Chimia 55 (2001) 1049-1052

47. Reymond JL
Exploring biocatalysis using catalytic antibodies.
Chimia 55 (2001) 330-333

48. Savel'ev AN, Kanyshkova TG, Kulminskaya AA, Buneva VN, Eneyskaya EV, Filatov MV, Nevinsky GA & Neustroev KN
Amylolytic activity og IgG and sIgA immunoglobins from human milk.
Clin. Chimica Acta 314 (2001) 141-152

49. Schermann MC, Boutboul A, Estramareix B, Hoffmann AS & Lubineau A
Binding properties and esterase activity of monoclonal antibodies elicited against sucrose 6-heptylphosphonate.
Carbohydrate Res. 334 (2001) 295-307

50. Schuman M, Lopez X, Karplus M & Gouverneur V
Synthesis of a novel diarylphosphinic acid: a distorted ground state mimic and transition state analogue for amide hydrolysis.
Tetrahedron 57 (2001) 10299-10307

51. Shabat D, Lode HN, Pertl U, Reisfeld RA, Rader C, Lerner RA & Barbas CF 3rd
In vivo activity in a catalytic antibody-prodrug system: antibody catalyzed etoposide prodrug activation for selective chemotherapy.
Proc. Natl. Acad. Sci. USA 98 (2001) 7528-7533

52. Sinha SC, Sun J, Miller GP, Wartmann M & Lerner RA
Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F.
Chem. Eur. J. 7 (2001) 1691-1702

53. Sinha SC, Sun J, Wartmann M & Lerner RA
Synthesis of epothilone analogues by antibody-catalyzed resolution of thiazole aldol synthons on a multigram scale. Biological consequences of C-13 alkylation of epothilones.
Chembiochem. 2 (2001) 656-665

54. Su D, Ren XJ, You DL, Li D, Mu Y, Yan GL, Zhang Y, Luo YM, Xue Y, Shen JC, Liu Z & Luo GM
Generation of three selenium-containing antibodies with high catalytic efficiency using a novel hapten design method.
Arch. Biochem. Biophys. 395 (2001) 177-184

55. Su D, You D, Ren X, Luo G, Mu Y, Yan G, Xue Y & Shen J
Kinetic study of a selenium-containing scfv catalytic antibody that mimics glutathione peroxidase.
Biochem. Biophys. Res. Commun. 285 (2001) 702-707

56. Su D, You D, Ren X, Luo G, Mu Y, Yan G, Xue Y & Shen J
Kinetic study of a selenium-containing scfv catalytic antibody that mimics glutathione peroxidase.
Biochem. Biophys. Res. Commun. 286 (2001) 189-194

57. Subauste MC, List B, Guan X, Hahn KM, Lerner R & Gilula NB
A catalytic antibody produces fluorescent tracers of gap junction communication in living cells.
J. Biol. Chem. 276 (2001) 49164-49168

58. Suchkov SV
Comparative study of catalytic (DNA-hydrolyzing) and cytotoxic properties of anti-DNA autoantibodies.
Bull. Exp. Biol. Med. 131 (2001) 353-355

59. Suchkov SV
Mechanisms underlying cytotoxicity of anti-DNA antibodies.
Bull. Exp. Biol. Med. 131 (2001) 475-478

60. Suchkov SV, Gabibov AG & Gnuchev NV
A phenomenon of DNA-abzyme cross-reactivity and its significance for the mechanisms of cytotoxicity and apoptosis.
Russian J. Dev. Biol. 32 (2001) 287-291

61. Suchkov SV, Gabibov AG, Alekberova ZS & Gnuchev NV
DNA-abzymes and their clinical value in systemic lupus erythematosus.
Terapevticeski arhiv. 73 (2001) 58-65

62. Sun J, Takahashi N, Kakinuma H & Nishi Y
Molecular evolution of catalytic antibodies in autoimmune mice.
J. Immunol. 167 (2001) 5775-5785

63. Takahashi N, Kakinuma H, Liu L, Nishi Y & Fujii I
In vitro abzyme evolution to optimize antibody recognition for catalysis.
Nature Biotechnol. 19 (2001) 563-567

64. Tanaka F, Kerwin L, Kubitz D, Lerner RA & Barbas III CF
Visuallizing antibody-catalyzed retro-aldol-retro-Michael reactions.
Bioorg. Med. Chem. Lett. 11 (2001) 2983-2986

65. Tantillo DJ & Houk KN
Canonical binding arrays as molecular recognition elements in the immune system: tetrahedral anions and the ester hydrolysis transition state.
Chem. Biol. 8 (2001) 535-545

66. Tremblay MR, Dickerson TJ & Janda KD
Advances in antibody catalysis of cycloaddition reactions.
Adv. Synth. Catal. 343 (2001) 577-585

67. Tsumuraya T, Takazawa N, Tsunakawa A, Fleck R & Masamune S
Catalytic antibodies induced by a zwitterionic hapten.
Chem. Eur. J. 7 (2001) 3748-3755

68. Wahler D & Reymond JL
Novel methods for biocatalyst screening.
Curr. Opin. Chem. Biol. 5 (2001) 152-158

69. Wang J, Han Y & Wilkinson MF
An active immunization approach to generate protective catalytic antibodies.
Biochem. J. 360 (2001) 151-157

70. Wentworth P & Janda KD
Catalytic antibodies: structure and function.
Cell Biochem. Biophys. 35 (2001) 63-87

71. Wentworth P, Jones LH, Wentworth AD, Zhu X, Larsen NA, Wilson IA, Xu X, Goddart WA, Janda KD, Eschenmoser A & Lerner RA
Antibody catalysis of the oxidation of water.
Science 293 (2001) 1806-1811

72. Worrall DS, McDunn JE, List B, Reichart D, Henever A, Gustafson T, Barbas CF 3rd, Lerner RA & Olefsky JM
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis.
Proc. Natl. Acad. Sci. USA 98 (2001) 13514-13518

73. Yin J, Mundorff EC, Yang PL, Wendt KU, Hanway D, Stevens RC & Schultz PG
A comparative analysis of the immunological evolution of antibody 28B4.
Biochemistry 40 (2001) 10764-10773

74. Yu JH, Huang QB, Ma DJ, Jia YF, Chu YC & Deng YD
Hydrolysis of carboxylate ester catalyzed by a new artificial abzyme based on molecular imprinted polymer.
Prog. Nat. Sci. 11 (2001) 516-519

75. Zhan CG & Landry DW
Theoretical studies of competing reaction pathways and energy barriers for alkaline ester hydrolysis of cocaine.
J. Phys. Chem. A 105 (2001) 1296-1301




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