2003


1. Aggarwal R, Benedetti F, Berti F, Buchini S, Colombatti A, Dinon F, Galasso V & Norbedo S
A catalytic antibody programmed for torsional activation of amide bond hydrolysis.
Chemistry 9 (2003) 132-142

2. Arno M & Domingo LR
Theozyme for antibody aldolases. Characterization of the transition-state analogue.
Org. Biomol. Chem. 1 (2003) 637-643.

3. Backes A, Hotta K & Hilvert D
Promiscuity in antibody catalysis: esterolytic activity of the decarboxylase 21D8.
Helv. Chim. Acta 86 (2003) 1167-1174

4. Bangale Y, Karle S, Planque S, Zhou YX, Taguchi H, Nishiyama Y, Li L, Kagala R & Paul S
VIPase autoantibodies in Fas-defective mice and patients with autoimmune disease.
FASEB J. 17 (2003) 628-635

5. Barnaby M, Gutierrez-De-Teran H, Sanz F, Villa-Freixa J & Warshel A
On the generation of catalytic antibodies by transition state analogues.
Chembiochem 4 (2003) 277-285

6. Bayry J, Lacroix-Desmazes S, Pashov A, Stahl D, Hoebeke J, Kazatchkine MD & Kaveri SV
Autoantibodies to factor VIII with catalytic activity.
Autoimmunity Rev. 2 (2003) 30-35

7. Breuer M & Hauer B
Carbon-carbon coupling in biotransformations.
Curr. Opin. Biotrchnol. (2003) in press

8. Buneva VN, Kudryavtseva AN, Gal'vita AV, Dubrovskaya VV, Khokhlova OV, Kalinina IA, Galenok VA & Nevinsky GA
Dynamics of antibody nuclease activity in blood of women during pregnancy and lactation.
Biochemistry Moscow 68 (2003) 890-900

9. Cannizzaro CE, Ashley JA, Janda KD & Houk KN
Experimental determination of the absolute enantioselectivity of an antibody-catalyzed Diels-Alder reaction and theoretical explorations of the origins of stereoselectivity.
J. Am. Chem. Soc. 125 (2003) 2489-2506

10. Cesaro-Tadic S, Lagos D, Honegger A, Rickard JH, Partridge LJ, Blackburn GM & Pluckthun A
Turnover-based in vitro selection and evolution of biocatalysts from a fully synthetic antibody library.
Nature Biotechnol. 21 (2003) 679-685

11. Chong LT, Bandyopadhyay P, Scanlan TS, Kuntz ID & Kollman PA
Direct hydroxyde attack is a plausible mechanism for amidase antibody 43C9.
J. Comput. Chem. 24 (2003) 1371-1377

12. Copley SD
Enzymes with extra talents: moonlighting functions and catalytic promiscuity.
Curr. Opin. Chem. Biol. 7 (2003) 265-272

13. Davis BG
Chemical modification of biocatalysts.
Curr. Opin. Biotechnol. 14 (2003) 379-386

14. Dickerson TJ, Tremblay MR, Hoffman TZ, Ruiz DI & Janda KD
Catalysis of the photo-fries reaction: antibody-mediated stabilization of high energy states.
J. Am. Chem. Soc. 125 (2003) 15395-15401

15. Dubrovskaya VV, Andryushkova AS, Kuznetsova IA, Toporkova LB, Buneva VN, Orlovskaya IA & Nevinsky GA
DNA-hydrolyzing antibodies from sera of autoimmune-prone MRL/MpJ-lpr mice.
Biochemistry Moscow 68 (2003) 1323-1332

16. Fernandez-Gacio A, Uguen M & Fastrez J
Phage display as a tool for the directed evolution of enzymes.
Trends Biotechnol. 21 (2003) 408-414

17. Franqueville E, Loutrari H, Mellou F, Stamatis H, Friboulet A & Kolisis FN
Reverse micelles, a system for antibody-catalysed reactions.
J. Mol. Catal. 21 (2003) 15-17

18. Gopin A, Pessah N, Shamis M, Rader C & Shabat D
A chemical adaptor system designed to link a tumor-targeting device with a prodrug and an enzyme trigger.
Angew. Chem. Int. Ed. 42 (2003) 327-332

19. Gordon DB, Hom GK, Mayo SL & Pierce NA
Exact rotamer optimization for protein design.
J. Comput. Chem. 24 (2003) 232-243

20. Gul S, Sonkania S, Pinitglang S, Florez-Alvarez J, Hussain S, Thomas EW, Ostler EL, Gallacher G, Resmini M & Brocklehurst K
Improvement in hydrolytic antibody activity by change in haptenic structure from phosphate to phosphonate with retention of a common leaving group determinant: unequivocal evidence for the flexibility hypothesis.
Biochem. J. 376 (2003) 813-821

21. Hatiuchi K, Hifumi E, Mitsuda Y & Uda T
Endopeptidase character of monoclonal antibody i41-7 subunits.
Immunol. Letters 86 (2003) 249-257

22. Hifumi E, Honko H, Mitsuda Y & Uda T
Catalytic features of monoclonal antibody i41SL1-2 subunits.
Biotechnol. Bioeng. 84 (2003) 485-493

23. Homayoun P, Mandal T, Landry D & Komiskey H
Controlled release of anti-cocaine catalytic antibody from biodegradable polymer microspheres.
J. Pharm. Pharmacol. 55 (2003) 933-938

24. Houk KN, Leach AG, Kim SP & Zhang X
Binding affinities of host-guest, protein-ligand, and protein-transition-state complexes.
Angew. Chem. Int Ed. 42 (2003) 4872-4897

25. Hur S & Bruice TC
Just a near attack conformer for catalysis (chorismate to prephenate rearrangements in water, antibody, enzymes and their mutants).
J. Am. Chem. Soc. 125 (2003) 10540-10542

26. Hur S & Bruice TC
The near attack conformation approach to the study of the chorismate to prephenate reaction.
Proc. Natl. Acad. Sci. USA 100 (2003) 12015-12020

27. Kantak KM
Vaccines against drugs of abuse. A viable treatment option?
Drugs 63 (2003) 341-352

28. Kawamura-Konishi Y, Sasaki R, Sugiyama M, Hashimoto H, Kamo T, Hosomi N, Yamazaki M, Tashiro H & Suzuki H
Key residue responsible for catalytic activities in the antibodies elicited against N-methyl mesoporphyrin.
J. Mol. Catal. 24-25 (2003) 99-109

29. Kienhofer A, Kast P & Hilvert D
Selective stabilization of the chorismate mutase transition state by a positively charged hydrogen bond donor.
J. Am. Chem. Soc. 125 (2003) 3206-3207

30. Kroon GJ, Mo H, Martinez-Yamout MA, Dyson HJ & Wright PE
Changes in structure and dynamics of the Fv fragment of a catalytic antibody upon binding of inhibitor.
Protein Sci. 12 (2003) 1386-1394

31. Lacroix-Desmazes S, Bayry J, Kazatchkine MD & Kaveri SV
Anticorps catalytiques ou abzymes.
Med. Sci. 19 (2003) 519-522

32. Lacroix-Desmazes S., Kazatchkine MD & Kaveri SV
Catalytic antibodies to factor VIII in haemophilia A.
Blood Coagul. Fibrinolysis SuP. 1 S3 (2003) 1-4

33. Latry V, Bayry J, Thorenoor N, Kazatchkine MD, Kaveri SV & Lacroix-Desmazes S
Biological functions of catalytic antibodies.
Transf. Med. Hemotherap. 30 (2003) 264-267

34. Lin Y, Tsumuraya T, Wakabayashi T, Shiraga S, Fujii I, Kondo A & Ueda M
Display of a functional hetero-oligomeric catalytic antibody on the yeast cell surface.
Appl. Microbiol. Biotechnol. 62 (2003) 226-232

35. Luo GM, Ren XJ, Liu JQ, Mu Y & Shen JC
Towards more efficient glutathione peroxidase mimics: substrate recognition and catalytic group assembly.
Curr. Med. Chem. 13 (2003) 1151-1183

36. Malthouse JPG
Stereospecificity of alpha-proton exchange reactions catalysed by pyridoxal-5'-phosphate-dependent enzymes.
Biochim. Biophys. Acta 1647 (2003) 138-142

37. Nevinsky GA & Buneva VN
Catalytic antibodies in healthy humans and patients with autoimmune and viral diseases.
J. Cell. Mol. Med. 7 (2003) 265-276

38. Nguyen HTT, Jang YJ, Jeong S & Yu J
DNA-specific autoantibody cleaves DNA by hydrolysis of phosphodiester and glycosidic bond.
Biochem. Biophys. Res. Commun. 311 (2003) 767-773

39. Nishi Y
Enzyme/abzyme prodrug activation systems: potential use in clinical oncology.
Curr. Pharm. Des. 9 (2003) 2113-2130

40. Padiolleau-Lefèvre S, Débat H, Thomas D, Friboulet A & Avalle B
In vivo evolution of a -lactamase activity throughout the idiotypic pathway.
Biocatal. Biotransf. 21 (2003) 79-85

41. Parren PWHI, Leusen JHW & Van de Winkel JGJ
Antibody catalyzed water oxidation: state-of-the-art immunity or ancient history?
Trends Immunol. 24 (2003) 467-469

42. Paul S, Planque S, Zhou YX, Tagichi H, Bhatia G, Karle S, Hanson C & Nishiyama Y
Specific HIV gp120 cleaving antibodies induced by covalently reactive analog of gp120.
J. Biol. Chem. 278 (2003) 20429-20435

43. Planque S, Taguchi H, Burr G, Bhatia G, Karle S, Zhou YX, Nishiyama Y & Paul S
Broadly distributed chemical reactivity of natural antibodies expressed in coordination with specific antigen binding activity.
J. Biol. Chem. 278 (2003) 20436-20443

44. Rader C, Sinha SC, Popkov M, Lerner RA & Barbas CF
Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst.
Proc. Natl. Acad. Sci. USA 100 (2003) 5396-5400

45. Rader C, Turner JM, Heine A, Shabat D, Sinha SC, Wilson IA, Lerner RA & Barbas CF
A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy.
J. Mol. Biol. 332 (2003) 889-899

46. Rangan SK, Liu R, Brune D, Planque S, Paul S & Sierks MS
Degradation of beta-amyloid by proteolytic antibody light chains.
Biochemistry 42 (2003) 14328-14334

47. Reth M
Hydrogen peroxide as second messenger in lymphocyte activation;
Nature Immunol. 3 (2003) 1129-1134

48. Robin S, Petrov K, Dintinger T, Kujumdzieva A, Tellier C & Dion M
Comparison of three microbial hosts for the expression of an active catalytic scFv.
Mol. Immunol. 39 (2003) 729-738

49. Ruzheinikov SN, Muranova TA, Sedelnikova SE, Partridge LJ, Blackburn GM, Murray IA, Kakinuma H, Takahashi-Ando N, Shimazaki K, Sun J, Nishi Y & Rice DW
High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity.
J. Mol. Biol. 332 (2003) 423-435

50. Saphier S, Sinha SC & Keinan E
Antibody-catalyzed enantioselective Norrish type II cyclization.
Angew. Chem. Int. Ed. 42 (2003) 1378-1381

51. Saveliev AN, Ivanen DR, Kulminskaya AA, Ershova NA, Kanyshkova TG, Buneva VN, Mogelnitskii AS, Doronin BM, Favorova OO, Nevinsky GA & Neustroev KN
Amylolytic activity of IgM and IgG antibodies from patients with multiple sclerosis.
Immunol. Letters 86 (2003) 291-297

52. Savinov SN, Hirschmann R, Benkovic SJ & Smith AB
Investigation of an antibody-ligase. Evidence for strain-induced catalysis.
Bioorg. Med. Chem. Lett. 13 (2003) 1321-1324

53. Sharma HA, Balcavage WX, Waite LR, Johnson MT & Nindl G
Characterization of a real time H2O2 monitor for use in studies on H2O2 production by antibodies and cells.
Biomed. Sci. Instrum. 39 (2003) 554-560

54. Strobel H, Ladant D & Jestin JL
In vitro selection for enzyme activity: a model study adenylate cyclase.
J. Mol. Biol. 332 (2003) 1-7

55. Sun LW, Liu LY & Zhao DQ
Chemical modification of abzyme with deiodinase activity.
Chem. J. Chin. Univ. Chin. 24 (2003) 588-590

56. Sun Y, Mu Y, Li W, Lv S, Jiang Z, Zhang K, Zheng K, Lin F, Yan G, Luo G, Liu J & Shen J
Protection of epidermal cells against UVB injury by the antioxydant selenium-containing single-chain Fv catalytic antibody.
Arch. Biochem. Biophys. 412 (2003) 90-94

57. Ujaque G, Tantillo DJ, Hu Y, Houk KN, Hotta K & Hilvert D
Catalysis on the coastline: theozyme, molecular dynamics, and free energy perturbation analysis of antibody 21D8 catalysis of the decarboxylation of 5-nitro-3-carboxybenzisoxazole.
J. Comput. Chem. 24 (2003) 98-110

58. Voice JK, Grinninger C, Kong Y, Bangale Y, Paul S, Goestzl EJ
Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type II VIP receptor transgenic mice.
J. Immunol. 170 (2003) 308-314

59. Wade H & Scanlan TS
Binding and catalysis: a thermodynamic study on a catalytic antibody system.
Chembiochem. 4 (2003) 537-540

60. Wentworth P Jr, Wentworth AD, Zhu X, Wilson IA, Janda KD, Eschenmoser A & Lerner RA
Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens.
Proc. Natl. Acad. Sci. USA 100 (2003) 1490-1493

61. Yin J, Andryski SE, Beuscher AE, Stevens RC & Schultz PG
Structural evidence for substrate strain in antibody catalysis.
Proc. Natl. Acad. Sci. USA 100 (2003) 856-861

62. You DL, Ren XJ, Xue Y, Luo GM, Yang TS & Shen JC
A selenium-containing single-chain abzyme with potent antioxidant activity.
Eur. J. Biochem. 270 (2003) 4326-4331

63. Yribarren AS, Thomas D, Friboulet A & Avalle B
Selection of peptides inhibiting a -lactamase-like activity.
Eur. J. Biochem. 270 (2003) 2789-2795

64. Zhan CG, Zheng F & Landry DW
Fundamental reaction mechanism for cocaine hydrolysis in human butyrylcholinesterase.
J. Am. Chem. Soc. 125 (2003) 2462-2474.

65. Zhao Y, Jiang N & Wang J
An efficient synthesis of a-aryl -(N-tosyl)amino phosphonate derivatives from a-diazophosphonate.
Tetrahedron Lett. 44 (2003) 8339-8342

66. Zheng L, Baumann U & Reymond JL
Production of a functional catalytic antibody ScFv-NusA fusion protein in bacterial cytoplasm.
J. Biochem. (Tokyo) 133 (2003) 577-581

67. Zhu X, Heine A, Monnat F, Houk KN, Janda KD & Wilson IA
Structural basis for antibody catalysis of a cationic cyclization reaction.
J. Mol. Biol. 329 (2003) 69-83




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