L'historique

L'approche des anti-idiotypes : de l'enzyme à l'abzyme

Les Anticorps catalytiques " naturels "

Les Métalloabzymes et Hémoabzymes

Les Applications Médicales et Industrielles

L. Pauling (1946) Molecular architecture and biological reactions. Chem. Eng. News 34, 1375-1377.

W.P. Jencks (1969) Catalysis in chemistry and enzymology. McGraw-Hill, New Yok.

G. Köhler & C. Milstein (1975) Continuous culture of fused cells secreting antibody of predefined specificity. Nature 256, 495-497.

F. Kohen, J.B. Kim, H.R. Lindner, Z. Eshhar & B.S. Green (1980) Monoclonal immunoglobulin G augments hydrolysis of an ester of the homologous hapten. FEBS Letters 111, 427-431.

A. Tramontano, K.D. Janda & R.A. Lerner (1986) Catalytic antibodies. Science 234, 1566-1570.

S.J. Pollack, J.W. Jacobs & P.G. Schultz (1986) Selective chemical catalysis by an antibody. Science 234, 1570-1573.

J.D. Stevenson & N.R. Thomas (2000) Catalytic antibodies and other biomimetic catalysts. Nat. Prod. Rep. 17, 535-577.

N.K. Jerne (1974) Toward a network theory of the immune system. Ann. Immunol. (Paris) 125C, 373-389.

L. Izadyar, A. Friboulet, M.H. Rémy, A. Roseto & D. Thomas (1993) Monoclonal anti-idiotypic antibodies as functional internal images of enzyme active sires. Production of a catalytic antibody with a cholinesterase activity. Proc. Natl. Acad. Sci. USA 90, 8876-8880.

R. Hu, G.Y. Xie, X. Zhang, Z.Q. Guo & S. Jin (1998) Production and characterization of monoclonal anti-idiotypic antibody exhibiting a catalytic activity similar to carboxypeptidase A. J. Biotechnol. 61, 109-115.

A.V. Kolesnikov, A.V. Kozyr, E.S. Alexandrova, F. Koralewski, A.V.Demin, M.I. Titov, B. Avalle, A. Tramontano, S. Paul, D. Thomas, A.G. Gabibov & A. Friboulet (2000) Enzyme mimicry by the antiidiotypic approach. Proc. Natl. Acad. Sci. USA 97, 13526-13531.

B. Avalle, D. Thomas & A. Friboulet (1998) Functional mimicry : elicitation of a monoclonal anti-idiotypic antibody hydrolyzing beta-lactams. FASEB J. 12, 1055-1060.

S. Paul, D.J. Volle, C.M. Beach, D.R. Johnson, M.J. Powell & R.J. Massey (1989) Catalytic hydrolysis of vasoactive intestinal peptide by human autoantibody. Science 244, 1158-1162.

S. Paul, S. Mei, B. Mody, E.H. Eklund, C.M. Beach, R.J. Massey & F. Hamel (1991) Cleavage of vasoactif intestinal peptide at multiple sites by autoantibodies. J. Biol. Chem. 266, 16128-16134.

Q.S. Gao, M. Sun, S. Tyutyulkova, D. Websters, A. Rees, A. Tramontano, R.J. Massey & S. Paul (1994) Molecular cloning of a proteolytic antibody light chain. J. Biol. Chem. 269, 32389-32393.

S. Paul, L. Li, R. Kalaga, P. Wilkins-Stevens, F.J. Stevens & A. Solomon (1995) Natural catalytic antibodies : peptide-hydrolyzing activities of Bence-Jones proteins and VL fragments. J. Biol. Chem. 270, 15257-15261.

L. Li, S. Paul, S. Tyutyulkova, M. Kazatchkine & S. Kaveri (1995) Catalytic activity of anti-thyroglobulin antibodies. J. Immunol. 154, 3328-3332.

S. Lacroix-Desmazes, A. Moreau, Sooryanarayana, C. Bonnemain, N. Stieltjes, A. Pashov, Y. Sultan, J. Hoebeke, M.D. Kazatchkine & S.V. Kaveri (1999) Catalytic activity of antibodies against factor VIII in patients with hemophilia A. Nature Medicine 5, 1044-1047.

A.M. Shuster , G.V. Gololobov, O.A. Kvashuk, A.E. Bogomolova, I.V. Smirnov & A.G. Gabibov (1992) DNA hydrolyzing autoantibodies. Science 256, 665-667.

B.L. Iverson & R.A. Lerner (1989) Sequence-specific peptide cleavage catalyzed by an antibody. Science 243, 1184-1188.

A.G. Cochran & P.G. Schultz (1990) Peroxidase activity of an antibody heme complexe. J. Am. Chem. Soc. 112, 9414-9415.

R. Quilez, S. de Lauzon, B. Desfosses, D. Mansuy & J.P. Mahy (1996) Artificial peroxidase-like hemoproteins based on antibodies constructed from a specifically designed o-carboxy substituted tetraarylporphyrin hapten and exhibiting a high affinity for iron-porphyrins. FEBS Letters 395, 73-76.

S. Nimri & E. Keinan (1999) Antibody-metalloporphyrin catalytic assembly mimics natural oxidation enzymes. J. Am. Chem. Soc. 121, 8978-8982.

Genetic Engineering News (1998) vol. 18 no.2.

Genetic Engineering News (1999) vol. 19 no.20.

H. Miyashita, Y. Karaki, M. Kikuchi & I. Fujii (1993) Prodrug activation via catalytic antibodies. Proc. Natl. Acad. Sci. USA 90, 5337-5340.

P. Wentworth, A. Datta, D. Blakey, T. Boyle, L. Partridge & G.M. Blackburn (1996) Toward antibody-directed " abzyme " prodrug therapy, ADAPT : carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing. Proc. Natl. Acad. Sci. USA 93, 799-803.

D.W. Landry, K. Zhao, G.X.Q. Yang, M. Glickmal & T.M. Georgiadis (1993) Antibody-catalyzed degradation of cocaine. Science 259, 2078-2080.