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Publications à partir de 2008

(selon les nouvelles catégories)

A - Revues avec comité de lecture (rang A)

A12-04 BENSAMOUN S.F., LECLERC G.E., DEBERNARD L. , CHENG X., ROBERT L., CHARLEUX F., RHEIN C., LATRIVE J.P. Cut-off values for alcoholic liver fibrosis using magnetic resonance elastography technique. Alcoholism: Clinical and Experimental Research, in press, 2012.
A12-11 CHU T.X., SALSAC A.-V., BARTHES-BIESEL D., GRISCOM L., EDWARDS-LEVY F., LECLERC E. Fabrication and in-situ characterization of microcapsules in a microfluidic system. Microfluidics & Nanofluidics, In Press, 2012.
A12-26 LECLERC E., KINOSHITA H., FUJII T., BARTHES-BIESEL D. Transient flow of microcapsules through convergent - divergent microchannels. Microfluidics and nanofluidic, 12:5, 761-770, 2012.
A12-27 LECLERC E., PROT J.M. Current status of alternatives in animal testing and methods in predictive toxicology using liver microfluidic biochips. Annals of biomedical engineering, press, 2012.
A12-28 LECLERC G.E., CHARLEUX F., ROBERT L., HO BA THO M.C., RHEIN C., LATRIVE J.P., BENSAMOUN S.F. Analysis of the liver viscosity behavior as a function of the Multifrequency Magnetic Resonance Elastography (MMRE) post-processing. J Magn Reson Imaging, 2012, In press
A12-29 LECLERC G.E., DEBERNARD L., FOUCART F., ROBERT L., PELLETIER K., CHARLEUX F., EHMAN R., HO BA THO M.C., BENSAMOUN S.F. Characterization of a hyper-viscoelastic phantom mimicking biological soft tissue using an abdominal pneumatic driver with magnetic resonance elastography (MRE). Journal of Biomechanics, 45, 952-957, 2012.
A12-03 BAUDOIN R., ALBERTO G., LEGALLAIS C., LECLERC E. Parallelized microfluidic biochips in multi well plate applied to liver tissue engineering. Sensor and actuactors B, en presse, 2012.
A12-07 CHENG S., PROT J.M., LECLERC E., BOIS F. Zonation-related pathways in human hepatocellular carcinoma cells in dynamic vs. static culture microenvironments. BMC Genomic, 13:54, 2012.
A12-08 CHOUCHA SNOUBER L., BUNESCU A., LEGALLAIS C., BROCHOT C., DUMAS M.E., ELENE-HERMANN B. , LECLERC E. Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips. Toxicological Science , en presse 2012.
A12-09 CHOUCHA SNOUBER L., JACQUES S., Monge M, LEGALLAIS C., LECLERC E. Transcriptomic analysis of the effect of the ifosfamide on MDCK cells cultivated in microfluidic biochips . Genomics, en presse 2012.
A12-10 CHOUCHA SNOUBER L., LETOURNEUR F., CHAFEY P., BROUSSARD C., MONGE M., LEGALLAIS C., LECLERC E. Analysis of transcriptomic and proteomic profiles demonstrates the improvement of the MDCK cell function in a renal microfluidic biochip. Biotechnology Progress , 28, 474-484, 2012.
A12-35 OUATTARA D. , PROT J.M., BUNESCU A., DUMAS M.E., ELENE-HERMANN B., LECLERC E., BROHOT C. Metabolomics-on-a-chip and metabolic flux analysis for a label-free modeling of the internal metabolism of HepG2/C3A cells in an in vitro microfluidic biochip. Molecular Biosystems , en presse, 2012.
A12-38 PROT J.M., BUNESCU A., ELENE-HERMANN B. , ANINAT C., CHOUCHA SNOUBER L., GRISCOM L., RAZAN F., BOIS F., LEGALLAIS C., BROCHOT C., CORLU A., DUMAS M.E., LECLERC E. Alternative method in predictive toxicology using systemic biology and liver microfluidic “on chip” approaches: application to acetaminophen injury. Toxicology and applied pharmacology, 259, 270-280, 2012.
A12-41 SHINTU L., BAUDOIN R., NAVRATIL V., PROT J.M., PONTOIZEAU C., DEFERNEZ M., BLAISE B., DOMANGE C., PERY A., TOULHOAT , LEGALLAIS C., BROCHOT C., LECLERC E., DUMAS M.E. Metabolomics-on-a-Chip and Predictive Systems Toxicology in Microfluidic Bioartificial Organs. Analytical chemistry, in press 2012.
A11-03 BAUDOIN R., GRISCOM L., PROT J-M., LEGALLAIS C., LECLERC E. Behavior of HepG2/C3A cell cultures in a microfluidic bioreactor. Biochemical Engineering Journal, Volume 53, Issue 2, 2011, 172-181.
A11-04 BENSAMOUN S.F., ROBERT L., LECLERC G., DEBERNARD L., CHARLEUX F. Stiffness imaging of the kidney and adjacent abdominal tissues measured simultaneously using magnetic resonance elastography (MRE). Clinical Imaging 35(4):284-287, 2011.
A11-07 CHU T.X., SALSAC A.-V., LECLERC E., BARTHES-BIESEL D., WURTZ H., EDWARDS-LEVY F. Comparison between measurements of elasticity and free amino group content for ovalbumin microcapsule membranes: discrimination of the cross-linking degree. J. Coll. Interf. Sci., 355, 81-88, 2011.
A11-31 PROT J.M., ANINAT C., GRISCOM L., BROCHOT C., GUGUEN-GUILLOUZO C., LEGALLAIS C., CORLU A., LECLERC E. Improvement of HepG2/C3A cell function in a microfluidic biochip. Biotechnology and Bioengineering, 108, 1704-1715, 2011
A11-32 PROT J.M., VIDEAU O., BROCHOT C., LEGALLAIS C., BENECH H., LECLERC E. A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte culture in a microfluidic biochip for pharmaceutical drug screening. International Journal of Pharmaceutics, 408, 67-75, 2011
A11-30 PROT J-M, BRIFFAUT A-S, LETOURNEUR F, CHAFEY P, MERLIER F, GRANVALET Y, LEGALLAIS C, LECLERC E Integrated Proteomic and Transcriptomic Investigation of the Acetaminophen Toxicity in Liver Microfluidic Biochip. PlosOne, 6, 21268- 21278, 2011.
A11-33 RAMELLO C, PAULLIER P, OULDDRIS A, MONGE M, LEGALLAIS C, LECLERC E Investigation into modification of mass transfer kinetics by acrolein in a renal biochip. Toxicology in vitro, 25, 1123-1131, 2011
A10-13 HE P. , BARTHES-BIESEL D., LECLERC E. Flow dynamics in flow-focusing microfluidic systems: effect of geometry. Microfluidics Nanofluidics, 9:2, 293- 298, 2010
A10-17 LECLERC E., DUVAL J.L., JALABERT L. Migration of liver and kidney explants inside trapezoidal PDMS microchannels. Material Science and Engineering C. 30:8, 1190-1196, 2010.
A10-21 OULDDRIS A., PAULLIER P., GRISCOM L., LEGALLAIS C., LECLERC E. Analysis of the mass transfers in an artificial kidney microchip. Journal of Membrane Science, 352, 116-125, 2010
A09-14 LECLERC E., DUVAL J.L., PEZRON I., NADAUD F. Behaviors of liver and kidney explants from chicken embryos inside plasma treated PDMS microchannels. Materials Science and Engineering C. 29, 861-868, 2009. Abstract)
A08-25 LECLERC E., EL KIRAT K., GRISCOM L. In situ micropatterning technique by cell crushing for co-cultures inside microfluidic biochips. Biomedical Microdevices, 10, 169-177, 2008. Abstract)
A08-26 LEFEBVRE Y., LECLERC E., BARTHES-BIESEL D., WALTER J., EDWARDS-LEVY F. Flow of artificial microcapsules in microfluidic channels: a method for determining the elastic properties of the membrane. Phys. Fluids 20, 123102 , 2008
A08-07 DUBUISSON D., TREIZEBRE A., HOUSSIN T., LECLERC E., BARTHES-BIESEL D., LEGRAND D., MAZURIER J., ARSCOTT S., BOCQUET B., SENEZ V. Nanoscale devices for online dielectric spectroscopy of biological cells. Physiological Measurement, 29, S213-S225, 2008

C - Conférences invitées

C10-05 BAUDOIN R., PROT J.M., LEGALLAIS C., LECLERC E. Microfluidic biochip as a new support for engineered tissues and in vitro studies of xenobiotics. 107th International Center of Biocybernetics Seminar : “Micro and Nanosystems in Biochemical Diagnosis – Principles and Applications”, ICB 2010, Mai 2010, Varsovie, Pologne.
C10-03 LECLERC E. Cell biochips for in vitro toxicity analysis Workshop on microfluidic for biology, Lorentz Center, Janvier 2010, Leiden, Pays Bas
C09-04 LECLERC E. Microfluidic and cell biochips for in vitro toxicity analysis Workshop meeting of the ANR/JST, call for programs 2009, Paris, France, French - Japanese Workshop in the field of Information and Communication Science and Technologies. French National Research Agency (ANR) and Japan Science and Technology Agency (JST), 19 - 20 of November, Paris.

D - Communications internationales avec actes et comité de lecture

D12-08 BENSAMOUN S.F., LECLERC G.E., CHARLEUX F., RHEIN C., LATRIVE J.P. Magnetic resonance elastography (MRE): a non invasive technique to identify the cut-off values for alcoholic liver fibrosis. 47th European Association for the study of the liver (EASL), Barcelona, Spain, 2012.
D12-27 LECLERC G.E., CHARLEUX F., RHEIN C., LATRIVE J.P., HO BA THO M.C., BENSAMOUN S.F. Viscoelastic properties of healthy and fibrotic liver with Magnetic Resonance Elastography. 18th Congress of the European Society of Biomechanics, Lisbon, Portugal, 2012.
D11-05 CHU T.X., LECLERC E., SALSAC A.-V., BARTHES-BIESEL D., GRISCOM L., Edwards-Lévy F. Online fabrication and characterization of capsule populations with a flow-focusing microfluidic system. 3rd Micro and Nano Flows Conference, Thessaloniki, Grèce, 22-24 Août 2011, 79, p1-7.
D11-15 LECLERC G., DEBERNAD L. , BENSAMOUN S., HO BA THO M.C. Characterization of phantom behavior with magnetic resonanceelastography (MRE) and finite element modeling 23th International Society of Biomechanics, 3-7 July, Brussels, Belgium.
D11-27 PROT J.M., ANINAT C., BAUDOIN R., GRISCOM L., LEGALLAIS C., CORLU A., LECLERC E. Influence of the dynamic micro environment on liver cells functionnality : a transcriptomic study. MMB, Lucerne, Suisse, 2011.
D10-40 CHOUCHA SNOUBER L., PROT J.M., BAUDOIN R., GRISCOM L., LEGALLAIS C., LECLERC E. Comparaison of cell culture in renal microfluidic bioreactor and Petri dishes. Termis 2010, Galway, Irlande, 2010
D10-41 CHOUCHA SNOUBER L., GRISCOM L., POLENI P.E., RAZAN F., BROCHOT C., ANINAT C., CORLU A., LEGALLAIS C., LECLERC E. Liver kidney microfluidic bioreactor for cell co-culture in drug studies. µTAs 2010, Groningen, Pays Bas, 3-7 Octobre, 2010
D10-49 CHU T.X., SALSAC A.-V., LECLERC E., BARTHES-BIESEL D., WURTZ H., EDWARDS-LEVY F. Measurement of microcapsule membrane elasticity using an inverse method: discrimination between populations. Microfluidics 2010, Toulouse, 8-10 Décembre 2010, μFLU10-098.
D10-50 HABKA D., PERY A., ANINAT C., CORLU A., LECLERC E., BROCHOT C. Calibration of PBPK models based on in vivo and in vitro data to describe complex biotransformation processes. Eurotox. XII International Congress of Toxycology, Barcelona, Espagne, 2010
D10-43 PROT J.M., BAUDOIN R., VIDEAU O., LEGALLAIS C., BENECH H., LECLERC E. Development of a liver microfluidic bioreactor for toxicity and drug metabolism investigations. 2nd Joint Meeting of Hepatocytes User Group & Medicon Valley Hepatocytes User Forum, HUG 2010, Montpellier, France, 2010.
D10-42 PROT J.M., VIDEAU O., LEGALLAIS C., BENECH H., LECLERC E. Performance of biotransformation of human primary hepatocytes exposed to a pharmaceutical cocktail inside a liver biochip. µTAs 2010, Groningen, Pays Bas, 3-7 Octobre, 2010
D09-23 LECLERC E., PROT J-M., BAUDOIN R., LEGALLAIS C., GRISCOM L. Microfluidic biochips as new supports for in vitro bioartificial organs and toxicity studies. XXXVI Annual Meeting European Society for Artificial Organs, Compiègne, France, 2-5 Sept 2009.
D09-30 PROT J-M., BAUDOIN R., GRISCOM L., LEGALLAIS C., LECLERC E. Comparison of the growth kinetics of hepatocarcinoma cells in a microfluidic bioreactor and Petri dishes MMB, Quebec, Canada, 2009
D09-31 PROT J-M., BAUDOIN R., GRISCOM L., LEGALLAIS C., LECLERC E. Use of a liver biochip as a tool in toxicological study XXXVI Annual Meeting European Society for Artificial Organs, Compiègne, France, 2-5 Sept 2009.
D08-06 BARTHES-BIESEL D., LECLERC E., LEFEBVRE Y., WALTER J., EDWARDS LEVY F. Flow of microcapsules in small pores : a method for determining the membrane elastic properties. ICTAM 2008, Australie.
D08-31 HE P., LECLERC E., BARTHES-BIESEL D., GRISCOM L., EDWARDS-LEVY F. Microdroplet formation in Y junctions: effect of the geometrical parameters on the microdroplet fabrication. 1st European Conference on Microfluidics - Microfluidics 2008 - Bologna, Decembre 10-12, 2008.
D08-45 PROT J.M., BAUDOIN R., GRISCOM L., LEGALLAIS C., LECLERC E. Growth characterisation of hepatocarcinoma cells cultivated in a microfluidic biochip, XXXV Annual Meeting European Society for Artificial Organs, Geneva, September 3-6, 2008.

E - Communications nationales avec actes et comité de lecture

E11-03 BAYET-ROBERT M., DESMOTS S., BROCHOT C., LECLERC E., DUMAS M.E., PERY A., ELENA-HERRMANN B. Etude pharmaco-métabonomique de la réponse toxique au paracétamol. 5èmes Journées Scientifiques du Réseau Français de Métabolomique et Fluxomique, RFMF, 2011.
E10-03 CHU T.X., SALSAC A.-V., LECLERC E., BARTHES-BIESEL D., EDWARDS-LEVY F. Measurement and discrimination of the membrane elasticity of microcapsule populations using an inverse method. 12èmes Journées de la Matière Condensée, Troyes, 23-27 Août 2010, p.45.
E08-15 HE P., LECLERC E., BARTHES-BIESEL D., GRISCOM L., EDWARDS-LEVY F. Fabrication of monodisperse microdroplets by means of microfluidic technology. The second ASICEF worshop on interdisciplinary research topics, Paris, June 2008 (Poster)

F - Séminaires et autres communications

F08-05 SALSAC A.V., BARTHES-BIESEL D., LEFEBVRE Y., WALTER J., LECLERC E. Capsule mechanics and fluid structure interactions Journées du GDR 'Interaction Fluides Structures Biologiques', Marseille, Juillet 2008

G - Brevets

G11-01 LECLERC E., BARTHES-BIESEL D., SALSAC A.-V., CHU T.X. Méthode de production et caractérisation des propriétés de membranes de populations de microcapsules. Brevet national FR1153526, 2011.
G10-02 LECLERC E., BAUDOIN R., PAULLIER P., LEGALLAIS C., PROT J.M. Demandes françaises «Boite multi reacteurs pour la culture cellulaire dynamique-1 » n° FR1051480, 2010
G10-03 LECLERC E., BAUDOIN R., PAULLIER P., LEGALLAIS C., PROT J.M. Demandes françaises «Boite multi reacteurs pour la culture cellulaire dynamique-2 » n° FR1051482, 2010
G10-01 DUMAS M.E., LECLERC E., SHINTU L., BAUDOIN R. , LEGALLAIS C., BROCHOT C., TOULHOAT P. Demande française « Procédé d'évaluation toxicologique, procédé de criblage toxicologique et système associé » n° FR1053732, 2010
G09-01 LECLERC E., LEGALLAIS C., BAUDOIN R. Bioréacteur pour cultiver des cellules, n°0954288, 2009 Demande Française
G09-02 LECLERC E., PAULLIER P., OULDDRIS A. Dispositif et système de filtration, n° FR0956568, 2009 Demande Française

I - HDR

I09-02 LECLERC E. Conception et développement de dispositifs microfluidiques et cellulaires. HDR soutenue le 6 avril 2009. Abstract)


Publications antérieures à 2008


A - Revues à Comité de lecture

A07-03 BAUDOIN R. CORLU A. GRISCOM L. LEGALLAIS C. LECLERC E. Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity. Toxicol. In vitro, 21, 535-544, 2007.
A07-04 BAUDOIN R. GRISCOM L. MONGE M. LEGALLAIS C. LECLERC E. Development of a renal microchip for in vitro distal tubule models. Biotechnol. Prog., 23, 1245-1253, 2007.
A07-18 LECLERC E. BAUDOIN R. CORLU A. GRISCOM L. DUVAL J.L. LEGALLAIS C. Selective control of liver and kidney cells migration during organotypic cocultures inside fibronectin-coated rectangular silicone microchannels. Biomaterials, 28, 1820-1829, 2007.
A06-24 LECLERC E. CORLU A. GRISCOM L. BAUDOIN R. LEGALLAIS C. Guidance of liver and kidney organotypic cultures inside rectangular silicone microchannels. Biomaterials, 27, 4109-4119, 2006.
A06-25 LECLERC E. DAVID B. GRISCOM L. LEPIOUFLE B. FUJII T. LAYROLLE P. LEGALLAIS C. Study of osteoblastic cells in a microfluidic environment. Biomaterials, 27, 586-595, 2006.
A06-26 LECLERC E. DAVID B. GRISCOM L. LEPIOUFLE B. FUJII T. SAKAI Y. LEGALLAIS C. Perfusion culture of mammalian cells in microfluidic environments for tissue engineering applications. La Houille Blanche, 3, 56-59,2006.

C - Communications dans les congrès avec comité de lecture

C07-04 BAUDOIN R. GRISCOM L. CORLU A. LAYROLLE P. LEGALLAIS C. LECLERC E. Development of a cellular biochip mimicking in vitro organs for chronic toxicity analysis. TransducersÂ’07, 14th International Conference on Solid-State Sensors, actuators and Microsystems, Lyon , France, Juin 2007.
C07-28 LECLERC E. WALTER J. LEFEBVRE Y. GRISCOM L. EDWARDS-LEVY F. BARTHES-BIESEL D. Behaviour of bioartifical capsules in microfluidic flows. µTAS, 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Paris, France, Octobre 2007.
C06-02 BARTHES-BIESEL D. LECLERC E. LEFEBVRE Y. WALTER J. Flow of bioartifical capsules in microchannels. 5th World Congress of Biomechanics, Munich, Juillet 2006. Keynote lecture.
C06-06 BAUDOIN R. GRISCOM L. LEGALLAIS C. LECLERC E. Development of a renal microfluidic device for future in vitro kidney model reconstruction. ESAO, Umea, Suède, Juin 2006.
C06-07 BAUDOIN R. GRISCOM L. LEGALLAIS C. LECLERC E. PDMS microdevices as new supports for in vitro bioartificial organs. XXXIII ESAO Congress, Umea, Juin 2006.
C06-05 BAUDOIN R. GRISCOM L. CORLU A. LEGALLAIS C LECLERC E. Development of a microfluidic devices for in vitro liver model. 5th World Congress of Biomechanics, Munich, Juillet 2006.
C06-36 LECLERC E. Conférence invitée: New in vitro cell culture tools based on cellular microchip. COE symposium, Tokyo, Japan, 2006.
C06-37 LECLERC E. CORLU A. GRISCOM L. BAUDOIN R. LEGALLAIS C. Liver organotypic chick embryo cultures on silicone microchannels. ESB 20th European Conference on Biomaterials, Nantes, Septembre 2006.
C06-65 WALTER J. LECLERC E. GRISCOM L. EDWARDS-LEVY F. BARTHES-BIESEL D. Experimental investigation of the behaviour of bioartificial capsule inside rectangular and cylindrical cross section microchannels. 5th World Congress of Biomechanics, Munich, Juillet 2006.
C05-25 LECLERC E. GRISCOM L. LEPIOUFLE B. GUGUEN-GUILLOUZO C. CORLU A. LEGALLAIS C. Investigation of Human Hepatoma cell line microfluidic devices. 3rd annual International IEEE EMBS special topic conference on microtechnologies in medicine and biology, Oahu Hawaii, Mai 2005.
C04-34 LECLERC E. DAVID B. WAROCQUIER-CLEROUT R GRISCOM L. LEPIOUFLE B. FUJII T. LEGALLAIS C. Behaviour of osteoblast-like cells in cellular microdevices. Congrès Micro Total Analyses Systems, Malmö, Septembre 2004.

D - Communications dans des colloques

D07-09 LECLERC E. LEFEBVRE Y. WALTER J. EDWARDS-LEVY F. BARTHES-BIESEL D. Flow of artificial microcapsules in microchannels: a method for measuring membrane elastic properties. mTAS, Paris, Octobre 2007.
D06-02 BAUDOIN R. GRISCOM L. CORLU A. LEGALLAIS C. LECLERC E. Development of microfluidic bioreactors for in vitro tissue reconstruction and chronic toxicity testing. National de la Société de Pharmacotoxicologie Cellulaire, Mars, Paris 2006.
D05-02 BAUDOIN R. GRISCOM L. LEPIOUFLE B. LEGALLAIS C. LECLERC E. Modèle tissulaire en environnement micro-fluidique. 17ème Congrès Français de Mécanique, Troyes, Août 2005.
D05-15 LECLERC E. DAVID B. GRISCOM L. LEPIOUFLE B. LEGALLAIS C. Interaction between microfluidic flows and mammalian cells inside cellular microdevices. 17ème Congrès Français de Mécanique, Troyes, Août 2005.
D04-06 LECLERC E. DAVID B. GRISCOM L. LEPIOUFLE B. SAKAI Y. FUJII T. LEGALLAIS C. Perfusion culture of mammalian cells in microfluidic environments for tissue engineering applications. Colloque SHF, 2ème congrès français de microfluidique, Toulouse, Décembre 2004.