Du 10 au 13 juillet 2023 à l'UTC.

On behalf of the Inter­na­tio­nal Union of Theo­re­ti­cal and Applied Mecha­nics and of the Uni­ver­si­té fran­co-alle­man­de/­Deutsch-Franzö­sische Hoch­schule, it is our great plea­sure and honour to wel­come you to the Sym­po­sium “Dyna­mics of Cap­sules, Vesicles and Cells in Flow”, which will take place at the Uni­ver­si­ty of Tech­no­lo­gy of Com­piègne (UTC) in Com­piègne, France. Loca­ted close to Paris (70 km away), Com­piègne is easy to reach: it is only 40 minutes away from Roissy/Charles de Gaulle and Paris-Beau­vais Inter­na­tio­nal airports.

The objec­tive of the Sym­po­sium is to bring toge­ther theo­re­ti­cians and expe­ri­men­ta­lists who work on the mecha­nics, phy­sics and bio­lo­gy of capsules/vesicles/cells. It will pro­vide the oppor­tu­ni­ty to confront the various approaches used to stu­dy such chal­len­ging par­ticles and esta­blish some gui­de­lines for future research.

Scope

The motion, defor­ma­tion and even­tual burst of cap­sules, vesicles and cells is chal­len­ging to stu­dy expe­ri­men­tal­ly, owing to the fra­gi­li­ty of the objects and their small size. They are also dif­fi­cult to com­pute, since the par­ticles are three-dimen­sio­nal clo­sed objects with an inner fluid core and a defor­mable mem­brane. They are sub­jec­ted to large defor­ma­tions by the exter­nal flow, which leads to stron­gly cou­pled fluid-struc­ture inter­ac­tions that are high­ly non-linear. Capsules/vesicles/cells thus also pro­vide fas­ci­na­ting fun­da­men­tal pro­blems in conti­nuum mecha­nics, besides having nume­rous prac­ti­cal appli­ca­tions, which are cru­cial to inves­ti­gate and optimize.

The objec­tive of the sym­po­sium is to bring toge­ther theo­re­ti­cians and expe­ri­men­ta­lists who work on the mecha­nics, phy­sics and bio­lo­gy of capsules/vesicles/cells. The pro­po­sed sym­po­sium will pro­vide the oppor­tu­ni­ty to make an over­view of recent expe­ri­men­tal deve­lop­ments (e.g. using micro­flui­dics and micro­rheo­lo­gy), confront the various mode­ling approaches and esta­blish a strong scien­ti­fic com­mu­ni­ty on the topic. Many scien­ti­fic issues indeed remain open:

• How per­ti­nent are the sim­pli­fying assump­tions that are inclu­ded in the latest nume­ri­cal models?
• What are cur­rent­ly the best models to des­cribe the phy­si­cal pro­per­ties of bio­lo­gi­cal cells, such as the Red Blood Cell?
• Which redu­ced-order models and arti­fi­cial intel­li­gence tech­niques are rele­vant to pre­dict the fluid-par­ticle inter­ac­tions with pre­ci­sion and help decrease the com­pu­ta­tio­nal cost?
• Which micro­flui­dic and micro­rheo­lo­gic tech­niques are now avai­lable to cha­rac­te­rize the mecha­ni­cal pro­per­ties of the capsule/vesicle/cell membrane?
• How does the fabri­ca­tion pro­cess influence the phy­si­cal and mecha­ni­cal pro­per­ties of arti­fi­cial cap­sule or vesicle?
• How to opti­mize the pay­load of the par­ticle and the resis­tance capa­ci­ty of the membrane?
• Which new appli­ca­tions in the fields of bio­tech­no­lo­gies, diag­nos­tics, pharmacology …?

The sym­po­sium will be the occa­sion to give a tri­bute to Prof Bar­thès-Bie­sel, who pio­nee­red research on cap­sule mecha­nics. We will look back at the miles­tones achie­ved over the 5 decades of her career and esta­blish some gui­de­lines for future research.

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