Anne-Virginie SALSAC

CNRS Researcher (CR1)

ith GIMP

Affiliation

Université de Technologie de Compiègne
Bioengineering Department
Biomechanics and Bioengineering Laboratory (BMBI, UMR CNRS 7338)  
     http://www.utc.fr/bmbi/

Address:      Biomechanics and Bioengineering Laboratory
                   Université de Technologie de Compiègne
                   CS 60319, 60203 Compiègne,  FRANCE

Tel:             +33 (0)3 44 23 73 38
Fax:            +33 (0)3 44 23 79 42
Email:          a.salsac@utc.fr

 

Education

2013                Habilitation à Diriger des Recherches, Université de Technologie de Compiègne

2007                PGCHE (Post-Graduate Certificate in Higher Education), University College London

2005                Ph.D., University of California, San Diego (USA). Joint degree with École Polytechnique (France)

2001                Master of Science, University of California, San Diego (USA)

2000                Engineering degree from ENSHMG – Ecole Nationale d’Hydraulique et Mécanique de Grenoble (France)

Present positions

Since 2014     Visiting Professor, Institute of Bioengineering, Queen Mary University of London, London (UK).

Since 2007      Researcher at the CNRS (National Center for Scientific Research) in the Biomechanics and Bioengineering Laboratory (UMR CNRS 7338), Université de Technologie de Compiègne (France).  

Past positions

2007 – 2011    Invited Researcher, Mechanical Engineering Department, University College London, Londres, Angleterre.

2006 – 2007    Lecturer in the Department of Mechanical Engineering, University College London (UK)

 

Awards

2000               Irwin and Joan Jacobs Fellow. Graduate Fellowship. UCSD.

2002 – 2004   Outstanding Teaching Assistant Awards, Mechanical & Aerospace Eng. Dept, UCSD.

2005               2 Best Poster Prices (Jacobs School of Engineering Best + ASME). UCSD Research Expo.

2005               Dissertation Fellowship, Mechanical and Aerospace Engineering Department, UCSD.

2005               Best Poster Price, 2005 Bioengineering Conference, Vail, Colorado.

Since 2011     Scientific Excellence Allowance (Prime d’Excellence Scientifique), CNRS.

2013               Best oral presentation. Euromech Colloquium 544, Grenoble, France.

2013               Young Researcher Award, Société de Biomécanique

2014               Invited Professor, Queen Mary University of London (UK)

2015               CNRS Bronze Medal

2015               ‘Trophée des Femmes en Or’ Innovation category + ‘Trophée du Public’ 

2016                Ordre National du Mérite (French National Order of Merit)

 

Research

My research is in the field of biofluids applied to vascular mechanics, microcirculation and biomedical engineering applications. It is focused on the study of physiological flows, coupling experimental and numerical approaches. I am interested in the fluid-structure interactions between blood flow and deformable structures (vessel wall, stent/graft, capsule or cell membrane, etc) and their coupling with other multiphysics phenomena (mass transfer, active stimulation such as ultrasounds, chemical reactions). I associate experimental, theoretical and numerical modelling to study the vascular system in a biomimetic approach and bioartificial system in a bioinspired approach. I work on the prediction of the system dynamic behaviour and develop patient- or object-specific techniques of characterization of their mechanical properties coupling experiments and theory.

- At the microscopic scale, I am interested in the mechanical behaviour of circulating capsules, whether they are bioartificial or natural ones (e.g. red blood cells). A capsule is a liquid droplet protected by a hyperelastic membrane. The objective is to determine the motion and deformation of capsules placed in an external flow. Different applications are under study: obtaining a better understanding of the deformation of a red blood cell in microcirculation, developing new techniques of encapsulation that rely on biocompatible capsules, studying the release mechanisms of an encapsulated substance and techniques to enhance the release, measuring the mechanical properties of micrometric capsules in batch, etc.

- At the scale of a blood vessel (macroscale), the objective is to better characterize the hemodynamics in physiological and diseased conditions (e.g. vascular diseases) and to study therapeutic techniques that are minimally invasive (embolisation, endografts).

 

Selected publications

Salsac A.-V., Sparks S.R., Lasheras J.C. Hemodynamic changes occurring during the progressive enlargement of abdominal aortic aneurysms. Ann. Vasc. Surg. 18: 14-21, 2004.

Salsac A.-V., Sparks S.R., Lasheras J.C. Changes in pressure and wall tension occurring during the enlargement of abdominal aortic aneurysms. Simplicity, Rigor and Relevance in Fluid Mechanics. Higuera F.J., Jiménez J., Vega J.M. (eds). CINME Barcelona, 269-281, 2004. Link

Salsac A.-V., Sparks S.R., Chomaz J.M., Lasheras J.C. Evolution of the wall shear stresses during the progressive enlargement of symmetric abdominal aortic aneurysms. J. Fluid Mech. 550: 19-51, 2006. Link

Walter J., Salsac A.-V., Barthès-Biesel D., Le Tallec P. Coupling of finite element and boundary integral methods for a capsule in a Stokes flow. Int. J. Numer. Meth. Engn. 83: 829-850 (2010). Link

Barthès-Biesel D., Walter J., Salsac A.-V. Flow-induced deformation of artificial capsules. In Computational Hydrodynamics of Capsules and Biological Cells. Taylor & Francis/CRC Press. C. Pozrikidis (ed), 27-62 (2010).

Chu T.X., Salsac A.-V., Leclerc E., Barthès-Biesel D, Wurtz H., Edwards-Lévy F. Comparison between measurements of elasticity and free amino group content for ovalbumin microcapsule membranes: discrimination of the cross-linking degree.  J. Coll. Interf. Sci. 355, 81-88 (2011). Link

Walter J., Salsac A.-V., Barthès-Biesel D. Ellipsoidal capsules in simple shear flow: prolate versus oblate initial shapes.  J. Fluid Mech. 676, 318 - 347 (2011). Link

Omori T., Ishikawa T., Barthès-Biesel D., Salsac A.-V., Walter J., Imai Y., Yamaguchi T. Comparison between spring network models and continuum constitutive laws: application to the large deformation of a capsule in shear flow. Phys. Rev. E. Stat. Nonlin. Soft Matter Phys. 83: 041918 (2011). Link

Foessel E., Walter J., Salsac A.-V., Barthès-Biesel D. Influence of internal viscosity on the deformation of a spherical capsule in a simple shear flow.  J. Fluid Mech. 672, 477-486 (2011). Link

Zhang L., Salsac A.-V. Can sonication enhance release from liquid-core capsules with a hydrogel membrane? J. Coll. Interf. Sci. 368: 648-654 (2011). Link

Hu X., Salsac A.-V., Barthès-Biesel D. Flow of a spherical capsule in a pore with circular or square cross-section.  J. Fluid Mech. 705: 176-194 (2012). Link

Sandulache M.-C., Paullier P., Bouzerar R., Yzet T., Balédent O., Salsac A.-V. Liquid injection in confined coflow: application to portal vein embolization by glue injection. Physics of Fluids. 24, 081902 (2012). Link

Omori T., Ishikawa T., Barthès-Biesel D., Salsac A.-V., Imai Y., Yamaguchi T. Tension of red blood cell membrane in simple shear flow. Phys. Rev. E. 86, 056321 (2012). Link

Chu T.X., Salsac A.-V., Barthès-Biesel D, Griscom L., Edwards-Lévy F., Leclerc E. Fabrication and in-situ characterization of microcapsules in a microfluidic system. Microfluidics & Nanofluidics. 14, 309-317 (2013). Link

Dupont C., Salsac A.-V., Barthès-Biesel D. Off-plane motion of a prolate capsule in shear flow.  J. Fluid Mech. 721, 180-198
(2013). Link

Capone S.H., Dufresne M., Rechel M., Fleury M.-J., Salsac A.-V., Paullier P., Daujat-Chavanieu M., Legallais C. Impact of alginate composition on bead mechanical properties and encapsulated HepG2/C3A cell activities. Plos One. 8(4), e62032 (2013). Link

Salsac A.-V., Leclerc E., Barthès-Biesel D. Microfluidic technique for measuring microcapsules. Bioencaps. Innov. 3, 12-14 (2013).

Hu X.-Q., Sévénié B., Salsac A.-V., Leclerc E., Barthès-Biesel D. Characterization of membrane properties of capsules flowing in a square-section microfluidic channel: effects of the membrane constitutive law. Phys. Rev. E. 87, 063008 (2013). Link

Decorato I., Kharboutly Z., Legallais C., Salsac A.-V. Hemodynamics inside autologous arteriovenous fistulas. In Medical Devices Design in Cardiovascular Applications. MeDDiCA, UCL, 197-225 (2013).

Chu T.-X., Salsac A.-V., Leclerc E., Barthès-Biesel D. Automatic evaluation of the elastic modulus of a capsule membrane. In Advances in Intelligent and Soft Computing, Vol 2. Ed: V.N. Huynh et al., Springer-Verlag, 389-398 (2013).

Salsac A.-V., Leclerc E., Barthès-Biesel D. Microfluidic technique for measuring microcapsules. Bioencapsulation Innovations. 3, 12-14 (2013).

Fréville V., Van Hecke E., Ernenwein C., Salsac A.-V., Pezron I. Effect of surfactants on the deformation and detachment of oil droplets in a model laminar flow cell. Oil & Gas Science and Technology. 69, 435-444 (2014). Link

Decorato I., Kharboutly Z., Legallais C., Penrose J., Salsac A.-V. Numerical simulation of the fluid structure interactions in a compliant patient-specific arteriovenous fistula. Int. J. Num. Meth. Biomed. Eng. 30, 143–159 (2014). Link

Decorato I., Kharboutly Z., Legallais C., Salsac A.-V. Comparison of two endovascular treatments of a stenosed arteriovenous fistula: balloon-angioplasty with and without stenting. International Journal of Artificial Organs. 10, 763-772 (2014). Link

Decorato I., Salsac A.-V., Legallais C., Alimohammadi M., Diaz-Zuccarini V., Kharboutly Z. Numerical simulation of the treatment of an arterial stenosis in an arteriovenous fistula by balloon-angioplasty. Cardiovasc. Eng. Technol. 5(3), 233-243 (2014). Link

Dupont C., Le Tallec P., Barthès-Biesel D., Vidrascu M., Salsac A.-V. Dynamics of a spherical capsule in a planar hyperbolic flow: influence of bending resistance. Procedia IUTAM. 16, 70-79 (2015). Link

Sévénié B., Barthès-Biesel D., Salsac A.-V. Flow of a capsule in a channel: effect of non-squareness. Procedia IUTAM. 16, 106-114 (2015). Link

Dupont C., Salsac A.-V., Barthès-Biesel D., Vidrascu M., Le Tallec P. Influence of bending resistance on the dynamics of a capsule in shear flow. Physics of Fluids. 27, 051902 (2015). Link

Dupont C., Delahaye F., Barthès-Biesel D., Salsac A.-V. Stable equilibrium configurations of an oblate capsule in shear flow.  Journal of Fluid Mechanics. 791, 738-757 (2016). Link

Gires P.-Y., Barthès-Biesel D., Leclerc E., Salsac A.-V. Transient behavior and relaxation of microcapsules with a cross-linked serum albumin membrane. Journal of the Mechanical Behavior of Biomedical Materials. 58, 2-10 (2016). Link

Gubspun J., Gires P.-Y., de Loubens C., Barthès-Biesel D., Deschamps J., Georgelin M., Léonetti M., Leclerc E., Edwards-Lévy F., Salsac A.-V. Size and concentration effect on the mechanical properties of cross-linked albumin capsule membranes. Colloid and Polymer Science. 294, 1381–1389 (2016). Link

Wang Z., Sui Y. Salsac A.-V., Barthès-Biesel D., Wang W. Motion of a spherical capsule in branched tube flow with finite inertia. Journal of Fluid Mechanics. 806, 603-626 (2016). Link

Li Y., Barthès-Biesel D., Salsac A.-V. Embolization of blood vessels by glue injection: an in vitro study of polymerization kinetics. Journal of the Mechanical Behavior of Biomedical Materials. 69, 307–317 (2017). Link

Li Y., Barthès-Biesel D., Salsac A.-V. Polymerization kinetics of a mixture of Lipiodol and Glubran 2 cyanoacrylate glue upon contact with a proteinaceous solution. Journal of the Mechanical Behavior of Biomedical Materials. 74, 84–92 (2017). Link

Salsac A.-V., Modelling and characterization of microcapsules. Research Features, 109, 87-89 (2017). Link

Vesperini D., Chaput O., Munier N., Maire P., Edwards-Lévy F., Salsac A.-V., Le Goff A. Deformability- and size-based capsule sorting. Medical Engineering and Physics, In Press (2017). Link

Lignel S., Salsac A.-V., Drelich A., Leclerc E., Pezron I. Water-in-oil droplet formation in a flow-focusing microsystem using pressure- and flow rate-driven pumps. Colloids and Surfaces A, In Press (2017). Link

 

Patent

Method of production and characterization of the mechanical properties of microcapsules. French patent. WO2012143546, 2012.

 

Magazine / newspaper articles

May 2015       Article « Anne-Virginie Salsac, au sommet de la recherche », Agir en Picardie Link

http://www.picardie.fr/Anne-Virginie-Salsac-au-sommet-de 

Dec 2015        Article « Bon Sang Ne Saurait Mentir », Actives Magazine, Link

Jan 2016         Article « Une brillante chercheuse récompensée », Dernières Nouvelles d’Alsace, Link

Feb 2016         Article « De l’Or à l’UTC », Interactions-UTC, Link

March 2016    Article « Anne-Virginie Salsac et la petite mécanique du corps humain », CNRS - Le Journal, Link

March 2016    Television - Les Femmes en Or 2015 « Anne-Virginie Salsac », TEVA

http://www.teva.fr/serie-velvet/videos/11557522-le_portrait_de_anne_virginie_salsac.html 

Oct 2016         Article : « La force de la recherche en France, c’est l’esprit collectif », J'Innove en Hauts-de-France, Link

 

 

Research projects

2006 - 2007    Royal Society First Grant. Deformation of droplets in circulation: application to the study of cells in circulation. PI

2006 - 2007    Royal Society Wolfson Laboratory Refurbishment. Department de Mechanical Engineering à UCL. Partner

2007 - 2010    Projet de Recherche Structurant – Région Picardie. MicroFIEC - Microfluidic systems for encapsulation. Partner

2008 - 2011    Projet de Recherche Structurant – Région Picardie. EMBOLOTHERAPIE – In vitro/in vivo characterization of the endovascular technique of vessel embolization by glue injection. PI

2009 - 2013    Marie Curie Initial Training Network FP7. MeDDiCA - Medical devices design in cardiovascular applications. PI

2010 - 2013    Projet de Recherche Structurant – Région Picardie. MODCAP – Modelling of capsules, vesicules and cells in flow. PI

2011 - 2015    ANR Blanche. CAPSHYDR - Fabrication, characterization and modelling of CAPSules under HYDRodynamic constraints. PI

2012 - 2015    Labex MS2T. Capsule in flow in a bifurcated channel. PI

2013                1st Price, UTC Innovative project competition. Calibrated microencapsulation. PI

2013 - 2016    Projet de Recherche Structurant – Région Picardie. Flowface – In vivo quantification and numerical characterization of blood flows in the vascular vasculature of the cervico-facial region under normal and pathological situations. Partner

2015 – 2016    Emergence – Sorbonne Université. B3Caps – Buckling and Breakup of Biocapsules. PI

2015 – 2017    International Partnerships – Royal Society. DYMPCAPS –Dynamic Motion of Capsules in Flow. Partner

2015 – 2018    Collège doctoral Sorbonne Universités. Fluid-structure modelling of a cell in flow. PI

2015 – 2018    Projet de Recherche Structurant – Région Picardie. WONDERFUL - Wise OptimizatioN and Deep Enhancement of Redox Flow batteries through ULtimate modeling. Partner

2015 – 2018    Accueil Chercheur Haut Niveau – Région Picardie. FORPLAQ – Biomechanics of the formation of platelets. Partner

2016 – 2020    Projet de Recherche Structurant – Région Picardie. CapsAntiOx – Microencapsulation de molécules antioxydantes pour l’enrichissement des produits alimentaires. PI

Teaching

Current teaching includes:

    Université de Technologie de Compiègne

   
Past teaching has also included:

     Université de Technologie de Compiègne

     University College London

    University of California, San Diego

 

Organization of scientific meetings

 

Institutional responsibilities

Université de Technologie de Compiègne

    Centre National de la Recherche Scientifique (CNRS)

Other responsibilities

Editorial activity

 

Related webpages

University of California, San Diego
Ecole Polytechnique
University College London
Université de Technologie de Compiègne

Queen Mary University of London

CNRS Research group: GDR ('Groupement de Recherche') MECABIO

 

Acknowledgements 

I would like to acknowledge the support of:

·       European Commission

·       Agence Nationale de la Recherche (ANR)

·       Région Picardie – Hauts-de-France

·       Centre National de la Recherche Scientifique (CNRS)

·       Université de Technologie de Compiègne (UTC)

·       Sorbonne Universités

·       Labex (MS2T)

·       Fondation des Gueules Cassées

·       International Union of Theoretical and Applied Mechanics (IUTAM)

·       European Mechanics Society (Euromech)

·       Association Française de Mécanique (AFM)

·       Société de Biomécanique (SB)