Anne-Virginie SALSAC

CNRS Researcher


Affiliation

Université de Technologie de Compiègne
Bioengineering Department
Biomechanics and Bioengineering Laboratory (BMBI, UMR CNRS 7338)  
     http://www.utc.fr/bmbi/

Address:      Laboratoire Biomécanique et Bioingénierie
                   Université de Technologie de Compiègne
                   B.P. 20529, 60205 Compiègne,  FRANCE

Tel:             +33 (0)3 44 23 73 38
Fax:            +33 (0)3 44 23 79 42
Email:          a.salsac@utc.fr
 

Education

2007                PGCHE (Post-Graduate Certificate in Higher Education), University College London

2005                Ph.D., University of California, San Diego (USA) and École Polytechnique (France), with J.C. Lasheras, J.M. Chomaz

2001                Master of Science, University of California, San Diego (USA)

2000                Engineering degree from ENSHMG – Ecole Nationale d’Hydraulique et Mécanique de Grenoble (France)

Present positions

2007 –             Researcher at the C.N.R.S. (National Center for Scientific Research) in the Biomechanics and Biomedical Engineering Laboratory, Université de Technologie de Compiègne (France).   

2007 –             Invited researcher in the Department of Mechanical Engineering, University College London (UK)

Past positions

2006 – 2007    Lecturer in the Department of Mechanical Engineering, University College London (UK)


Research

My research is in the field of biofluids applied to vascular mechanics, microcirculation and biomedical engineering applications. It is mainly focused on the study of physiological flows, coupling experimental and numerical approaches.

- At the scale of a blood vessel (macroscale), I am interested in the fluid-structure interactions between blood flow and deformable structures (vessel wall, stent/graft, etc). The objective is a better characterization of hemodynamics in physiological and diseased conditions (e.g. vascular diseases). Another objective is the study of therapeutic techniques that are minimally invasive (embolisation, endografts).

- At the microscopic scale, I am interested in the mechanical behaviour of circulating capsules, whether they are bioarticial or natural ones (e.g. red blood cells). A capsule is a liquid droplet protected by a hyperelastic membrane. The objective is to determine the motion and deformation of capsules placed in an external flow. Different applications are under study: obtaining a better understanding of the deformation of a red blood cell in microcirculation, developing new techniques of encapsulation that rely on biocompatible capsules, studying the release mechanisms of an encapsulated substance and techniques to enhance the release, measuring the mechanical properties of micrometric capsules in batch, etc.


Teaching

Current teaching includes:

    Université de Technologie de Compiègne

     University College London

Past teaching has also included:

     Université de Technologie de Compiègne

     University College London

    University of California, San Diego


Selected publications

Salsac A.-V., Sparks S.R., Lasheras J.C. Hemodynamic changes occurring during the progressive enlargement of abdominal aortic aneurysms. Ann. Vasc. Surg. 18: 14-21, 2004.

Salsac A.-V., Sparks S.R., Lasheras J.C. Changes in pressure and wall tension occurring during the enlargement of abdominal aortic aneurysms. Simplicity, Rigor and Relevance in Fluid Mechanics. Higuera F.J., Jiménez J., Vega J.M. (eds). CINME Barcelona, 269-281, 2004.

Salsac A.-V., Sparks S.R., Chomaz J.M., Lasheras J.C. Evolution of the wall shear stresses during the progressive enlargement of symmetric abdominal aortic aneurysms. J. Fluid Mech. 550: 19-51, 2006.

Walter J., Salsac A.-V., Barthès-Biesel D., Le Tallec P. Coupling of finite element and boundary integral methods for a capsule in a Stokes flow. Int. J. Numer. Meth. Engn. 83: 829-850 (2010).

Barthès-Biesel D., Walter J., Salsac A.-V. Flow-induced deformation of artificial capsules. In Computational Hydrodynamics of Capsules and Biological Cells. Taylor & Francis/CRC Press. C. Pozrikidis (ed), 27-62 (2010).

Chu T.X., Salsac A.-V., Leclerc E., Barthès-Biesel D, Wurtz H., Edwards-Lévy F. Comparison between measurements of elasticity and free amino group content for ovalbumin microcapsule membranes: discrimination of the cross-linking degree.  J. Coll. Interf. Sci. 355, 81-88 (2011).

Walter J., Salsac A.-V., Barthès-Biesel D. Ellipsoidal capsules in simple shear flow: prolate versus oblate initial shapes.  J. Fluid Mech. 676, 318 - 347 (2011).

Omori T., Ishikawa T., Barthès-Biesel D., Salsac A.-V., Walter J., Imai Y., Yamaguchi T. Comparison between spring network models and continuum constitutive laws: application to the large deformation of a capsule in shear flow. Phys. Rev. E. Stat. Nonlin. Soft Matter Phys. 83: 041918 (2011).

Foessel E., Walter J., Salsac A.-V., Barthès-Biesel D. Influence of internal viscosity on the deformation of a spherical capsule in a simple shear flow.  J. Fluid Mech. 672, 477-486 (2011).

Hu X., Salsac A.-V., Barthès-Biesel D. Flow of a spherical capsule in a pore with circular or square cross-section.  J. Fluid Mech. 10.1017/jfm.2011.462 (2011).

Zhang L., Salsac A.-V. Can sonication enhance release from liquid-core capsules with a hydrogel membrane? J. Coll. Interf. Sci. 10.1016/j.jcis.2011.11.038 (2011).

Sandulache M.-C., Paullier P., Bouzerar R., Yzet T., Balédent O., Salsac A.-V. Liquid injection in confined coflow: application to portal vein embolization by glue injection. Physics of Fluids. 24, 081902 (2012).

Chu T.X., Salsac A.-V., Barthès-Biesel D, Griscom L., Edwards-Lévy F., Leclerc E. Fabrication and in-situ characterization of microcapsules in a microfluidic system. Microfluidics & Nanofluidics. In Press (2012).

Omori T., Ishikawa T., Barthès-Biesel D., Salsac A.-V., Imai Y., Yamaguchi T. Tension of red blood cell membrane in simple shear flow. Phys. Rev. E. In Press (2012).

Dupont C., Salsac A.-V., Barthès-Biesel D. Off-plane motion of a prolate capsule in shear flow.  J. Fluid Mech. In revision (2012).


Patent


Method of production and characterization of the mechanical properties of microcapsules. French patent. FR1153526, 2011.

Related webpages

University of California, San Diego
Ecole Polytechnique
University College London
Université de Technologie de Compiègne

CNRS Research group: GDR 2760 ('Groupement de Recherche') on Biological Fluid Structure Interactions