Research

My research is in the field of biofluids applied to vascular mechanics, microcirculation and biomedical engineering applications. It is focused on the study of physiological flows, coupling experimental and numerical approaches. I am interested in the fluid-structure interactions between blood flow and deformable structures (vessel wall, stent/graft, capsule or cell membrane, etc) and their coupling with other multiphysics phenomena (mass transfer, active stimulation such as ultrasounds, chemical reactions). I associate experimental, theoretical and numerical modelling to study the vascular system in a biomimetic approach and bioartificial system in a bioinspired approach. I work on the prediction of the system dynamic behaviour and develop patient- or object-specific techniques of characterization of their mechanical properties coupling experiments and theory.


Microscopic scale

I am interested in the mechanical behaviour of circulating capsules, whether they are bioartificial or natural ones (e.g. red blood cells). A capsule is a liquid droplet protected by a hyperelastic membrane. The objective is to determine the motion and deformation of capsules placed in an external flow. Different applications are under study: obtaining a better understanding of the deformation of a red blood cell in microcirculation, developing new techniques of encapsulation that rely on biocompatible capsules, studying the release mechanisms of an encapsulated substance and techniques to enhance the release, measuring the mechanical properties of micrometric capsules in batch, etc.

Numerical simulation of bioartificial capsules and cells in flow

Capsules
and microfluidics

Release of encapsulated substance


Macroscopic scale

At the scale of a blood vessel (macroscale), the objective is to better characterize the hemodynamics in physiological and diseased conditions (e.g. vascular diseases) and to study therapeutic techniques that are minimally invasive (embolisation, endografts).

Hemodynamics in large blood vessels

Minimally invasive therapeutic techniques